Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Novel streptogramin antibiotics
Autore:
Bonfiglio, G; Furneri, PM;
Indirizzi:
Univ Catania, Dipartimento Sci Microbiol, I-95124 Catania, Italy Univ Catania Catania Italy I-95124 Sci Microbiol, I-95124 Catania, Italy
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 2, volume: 10, anno: 2001,
pagine: 185 - 198
SICI:
1354-3784(200102)10:2<185:NSA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO ACTIVITY; RESISTANT ENTEROCOCCUS-FAECIUM; RP-59500 QUINUPRISTIN DALFOPRISTIN; VIRGINIAMYCIN-LIKE ANTIBIOTICS; COMPARATIVE INVITRO ACTIVITY; STAPHYLOCOCCAL PLASMID GENE; SKIN-STRUCTURE INFECTIONS; 23S RIBOSOMAL-RNA; RP 59500; STREPTOCOCCUS-PNEUMONIAE;
Keywords:
antibiotics; Enterococcus faecium; Gram-positive bacteria; streptogramin; quinupristin/dalfopristin; vancomycin-resistant enterococci;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Bonfiglio, G Univ Catania, Dipartimento Sci Microbiol, Via Androne 81, I-95124 Catania,Italy Univ Catania Via Androne 81 Catania Italy I-95124 ania,Italy
Citazione:
G. Bonfiglio e P.M. Furneri, "Novel streptogramin antibiotics", EXPERT OP I, 10(2), 2001, pp. 185-198

Abstract

Streptogramins represent a unique class of antibiotics remarkable for their antibacterial activity and their unique mechanism of action. These antibiotics are produced naturally as secondary metabolites by a number of Streptomyces species and have been classified into two main groups. They consist of at least two structurally unrelated compounds, group A or M (macrolactones) and group B or S (cyclic hexadepsipeptides). Both groups bind bacterialribosomes and inhibit protein synthesis at the elongation step and they act synergistically in vitro against many microorganisms. Streptogramins A and B act synergistically in vivo; the mixture of the two compounds is more powerful than the individual components and their combined action is irreversible. The pharmacokinetic parameters of group A and B streptogramins in blood are similar. The major gap, limiting the therapeutic use of the naturalcompounds, was represented by the lack dissolution in water. The synthesisof water-soluble derivatives of pristinamycin I-A and IIB has allowed the development of injectable, first represented by quinupristin/dalfopristin (Synercid(TM)) and oral formulations, represented by RPR-106372, streptogramins with fixed compositions. Streptogramins have demonstrated activity against Gram-positive microorganisms in vitro and in vivo, including those withmulti-drug resistance. Moreover, the absence of cross-resistance to macrolides in many of these microorganisms and the rarity of cross-resistance between the two groups of antibiotics associated with the rapid bacterial killing are the principal features of the streptogramins, offering the possibility for treating the rising number of infections that are caused by multi-resistant Gram-positive bacteria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:20:13