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Titolo:
Effects of ajmaline on rate-dependent atrioventricular node properties - Potential role in experimental atrioventricular re-entrant tachycardia
Autore:
Nayebpour, M; Naseri, M; Khori, V;
Indirizzi:
Tehran Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Tehran, Iran Tehran Univ Med Sci Tehran Iran Dept Pharmacol & Toxicol, Tehran, Iran Shahid Beheshti Univ Med Sci, Fac Med, Dept Pharmacol, Tehran, Iran ShahidBeheshti Univ Med Sci Tehran Iran , Dept Pharmacol, Tehran, Iran
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 412, anno: 2001,
pagine: 77 - 89
SICI:
0014-2999(20010119)412:1<77:EOAORA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL-CHARACTERISTICS; CONDUCTION; DOGS; STIMULATION; PROPAFENONE; ADENOSINE; LIDOCAINE; REENTRY; PATHWAY; HEARTS;
Keywords:
ajmaline; AV node; re-entry; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Nayebpour, M Tehran Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, POB19835-355, Tehran, Iran Tehran Univ Med Sci POB 19835-355 Tehran Iran Tehran, Iran
Citazione:
M. Nayebpour et al., "Effects of ajmaline on rate-dependent atrioventricular node properties - Potential role in experimental atrioventricular re-entrant tachycardia", EUR J PHARM, 412(1), 2001, pp. 77-89

Abstract

Ajmaline is a well-known atrioventricular (AV) node depressant agent, but its effects on functional properties of the AV node and on experimental AV re-entrant tachycardia have not been explored. The aims of the present study were (1) to determine whether ajmaline administration modifies the rate-dependent properties of the AV node and (2) to correlate these changes with the actions of ajmaline on an in vitro model of AV re-entrant tachycardia. Selective stimulation protocols and mathematical formulations were used to quantify independently AV node recovery, facilitation, and fatigue in 10 isolated rabbit AV nodes. Ajmaline decreased facilitation and fatigue and hadno significant effect on AV node recovery. The most important effect of ajmaline was rate-induced prolongation of AV node effective refractory period, resulting in a greater increase in tachycardia cycle length. AV re-entrant tachycardia was sustained when AV effective refractory period divided to tachycardia cycle length was less than 1, ajmaline suppressed AV re-entranttachycardia by increasing the slope of the AV effective refractory period divided to tachycardia cycle length versus tachycardia rate relation, causing the critical ratio of 1 to be attained at a slower rate. A mathematical model incorporating quantitative descriptors of recovery, facilitation, andfatigue accounted for changes in nodal conduction time, AV effective refractory period, tachycardia cycle length, and AV effective refractory period divided to tachycardia cycle length under all conditions. It can be concluded that (1) ajmaline increases AV conduction time, decreases AV node fatigue, and facilitation, without altering AV node recovery. (2) Ajmaline significantly prolongs AV effective refractory period in a rate-dependent manner. (3) These changes play a role in ajmaline's actions on experimental AV re-entrant tachycardia. Ajmaline's ability to terminate re-entrant supraventricular tachycardia may be due, at least in part, to its ability to amplify the rate-induced prolongation of the nodal refractory period. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:40:46