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Titolo:
Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets
Autore:
Costa, S; Iravani, MM; Pearce, RKB; Jenner, P;
Indirizzi:
Univ London Kings Coll, GKT Sch Biomed Sci, Neurodegenerat Dis Res Ctr, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL r, London SE1 1UL, England
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 412, anno: 2001,
pagine: 45 - 50
SICI:
0014-2999(20010119)412:1<45:GCLNFC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGROSTRIATAL DOPAMINERGIC SYSTEM; PARKINSONIAN MONKEYS; GDNF; NEURONS; BRAIN; RECOVERY; DISEASE; MODEL; MICE;
Keywords:
dopamine; GDNF (glial cell line-derived neurotrophic factor); Parkinson's disease; MPTP primate; motor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Jenner, P Univ London Kings Coll, GKT Sch Biomed Sci, Neurodegenerat Dis Res Ctr, Hodgkin Bldg,Guys Campus, London SE1 1UL, England Univ London KingsColl Hodgkin Bldg,Guys Campus London England SE1 1UL
Citazione:
S. Costa et al., "Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets", EUR J PHARM, 412(1), 2001, pp. 45-50

Abstract

Glial cell line-derived neurotrophic factor (GDNF) has previously reduced motor deficits and preserved nigral dopamine neurones in rhesus monkeys with a unilateral MPTP-induced lesion of substantia nigra. We now report on the ability of GDNF to reverse motor deficits induced by parenteral administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to common marmosets resulting in bilateral degeneration of the nigrostriatal pathway. Prior to GDNF administration, all MPTP-treated animals showed akinesia or bradykinesia, rigidity, postural instability and tremor. Intraventricular injection of GDNF (10, 100 or 500 mug) at 9 and 13 weeks post MPTP treatment resulted in a concentration dependent improvement in locomotor activity and motor disability which became significant after administration of 100 and 500mug of GDNF. The most prominent improvements were in alertness, checking movements, and posture. It is concluded that intraventricular GDNF administration improves bilateral Parkinsonian motor disability following MPTP treatment and this may reflect an action of GDNF on remaining nigral dopaminergic neurones. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:52:02