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Titolo:
Luminal N alpha-methyl histamine stimulates gastric acid secretion in duodenal ulcer patients via releasing gastrin
Autore:
Konturek, PC; Konturek, SJ; Sito, E; Kwiecien, N; Obtulowicz, W; Bielanski, W; Hahn, EG;
Indirizzi:
Jagiellonian Univ, Sch Med, Dept Physiol, PL-31531 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31531 hysiol, PL-31531 Krakow, Poland Univ Erlangen Nurnberg, Dept Med, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany rg, Dept Med, Erlangen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 412, anno: 2001,
pagine: 181 - 185
SICI:
0014-2999(20010126)412:2<181:LNAHSG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; PARIETAL-CELLS;
Keywords:
histamine; N alpha-methyl histamine; gastrin; gastric acid secretion; Helicobacter pylori;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Konturek, SJ Jagiellonian Univ, Sch Med, Dept Physiol, 16 Grzegorzecka Str, PL-31531 Krakow, Poland Jagiellonian Univ 16 Grzegorzecka Str Krakow Poland PL-31531
Citazione:
P.C. Konturek et al., "Luminal N alpha-methyl histamine stimulates gastric acid secretion in duodenal ulcer patients via releasing gastrin", EUR J PHARM, 412(2), 2001, pp. 181-185

Abstract

N alpha -methyl histamine is an unusual histamine metabolite which is produced in the stomach infected by Helicobacter pylori and which was shown in animals to stimulate gastric acid secretion and to release gastrin in vitroisolated G-cells, but no information is available regarding its influence on gastric secretion and gastrin release in duodenal ulcer patients before and after H. pylori eradication. In this study, we compared the effects of intragastric administration of single or graded doses of N alpha -methyl histamine on gastric acid secretion and plasma gastrin levels in 16 male duodenal ulcer patients (aging from 35 to 48 years and weighing 65-82 kg) before and after the eradication of H. pylori. Furthermore, the gastric luminal histamine and gastrin contents were determined before and after H. pylori eradication. In H. pylori-infected duodenal ulcer patients, the intragastricapplication of N alpha -methyl histamine failed to affect gastric acid secretion or plasma gastrin levels. Following eradication of H. pylori, gastric luminal histamine and gastrin, and both basal gastric acid secretion and plasma gastrin levels, were significantly reduced. N alpha -methyl histamine given intragastrically in graded doses to such H. pylori-eradicated duodenal ulcer patients was found to increase dose-dependently gastric acid output reaching at a dose of 5 mg, about 80% of histamine maximum induced by i.v. infusion of 25 mug/kg h of histamine dihydrochloride. We conclude that Nalpha -methyl histamine is a potent luminally active stimulant of gastrin release and gastric acid secretion in H. pylori-eradicated patients when luminal histamine is low but is not effective in H. pylori infected patients when luminal histamine is enhanced, possibly due to desensitization of gastrin (G-cells) and acid-producing (parietal) cells by No alpha -methyl histamine produced excessively in H, pylori-infected stomach. (C) 2001 Publishedby Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 00:55:24