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Titolo:
Antipsychotic drugs classified by their effects on the release of dopamineand noradrenaline in the prefrontal cortex and striatum
Autore:
Westerink, BHC; Kawahara, Y; De Boer, P; Geels, C; De Vries, JB; Wikstrom, HV; Van Kalkeren, A; Van Vliet, B; Kruse, CG; Long, SK;
Indirizzi:
Univ Groningen, Ctr Pharm, Dept Med Chem, NL-9713 AV Groningen, Netherlands Univ Groningen Groningen Netherlands NL-9713 AV V Groningen, Netherlands Solvay Pharmaceut, NL-1380 DA Weesp, Netherlands Solvay Pharmaceut WeespNetherlands NL-1380 DA 380 DA Weesp, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 412, anno: 2001,
pagine: 127 - 138
SICI:
0014-2999(20010126)412:2<127:ADCBTE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; IN-VIVO; RECEPTOR ANTAGONIST; EXTRACELLULAR DOPAMINE; NEGATIVE SYMPTOMS; FRONTAL-CORTEX; RAT-BRAIN; INCREASES; AMISULPRIDE; RISPERIDONE;
Keywords:
antipsychotic drug; prefrontal cortex; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Westerink, BHC Univ Groningen, Ctr Pharm, Dept Med Chem, Deusinglaan 1, NL-9713 AV Groningen, Netherlands Univ Groningen Deusinglaan 1 Groningen Netherlands NL-9713 AV
Citazione:
B.H.C. Westerink et al., "Antipsychotic drugs classified by their effects on the release of dopamineand noradrenaline in the prefrontal cortex and striatum", EUR J PHARM, 412(2), 2001, pp. 127-138

Abstract

Dose-effect curves were established for the effects of the antipsychotic drugs haloperidol, clozapine, olanzapine, risperidone and ziprasidone on extracellular levels of dopamine and noradrenaline in the medial prefrontal cortex, and of dopamine in the striatum. Haloperidol was more effective in stimulating the release of dopamine in the striatum, whereas clozapine was much more effective in the medial prefrontal cortex. The efficacy of risperidone, olanzapine and ziprasidone did not differ for the two brain areas. Thebenzamides sulpiride and raclopride increased dopamine release in the striatum but did not affect the release of dopamine and noradrenaline in the medial prefrontal cortex. In the presence of dopamine/noradrenaline reuptake inhibitors, the benzamides strongly increased the release of dopamine-but not of noradrenaline-in the medial prefrontal cortex. The 5-HT2 receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol (MDL100,907) (800 nmol/kg) and the dopamine D-2 receptor antagonist raclopride (2 mu mol/kg) displayed a clear synergism in increasingthe release of dopamine in the medial prefrontal cortex. No such synergismwas seen in the case of noradrenaline. Go-administration of the 5-HT2 receptor agonist (+)-2,5-dimethoxy-4-iodoamphetamine HCl (DOI) (850 nmol/kg) with clozapine (10 mu mol/kg) or haloperidol(800 nmol/kg) blocked the increase in dopamine as well as noradrenaline in the medial prefrontal cortex. It is concluded that typical and non-benzamide atypical antipsychotics increase extracellular dopamine in the medial prefrontal cortex via a synergistic interaction by blocking 5-HT2 as well as dopamine D-2 receptors. The increase in extracellular noradrenaline in the medial prefrontal cortex that was observed after administration of antipsychotics is explained by inhibition of 5-HT2 receptors and not dopamine D-2 receptors. Finally, the significance of the classification of antipsychotic drugs based on their selective action on the release of dopamine and noradrenaline in the medial prefrontal cortex is discussed. In particular, the position of the benzamides is discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:17:20