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Titolo:
Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation
Autore:
Garderet, L; Bittencourt, H; Kaliski, A; Daniel, MT; Ribaud, P; Socie, G; Gluckman, E;
Indirizzi:
Hop St Antoine, Serv Hematol Greffe Moella, F-75571 Paris 12, France Hop St Antoine Paris France 12 l Greffe Moella, F-75571 Paris 12, France Hop St Antoine, Hematol Lab, F-75571 Paris, France Hop St Antoine Paris France F-75571 , Hematol Lab, F-75571 Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF HAEMATOLOGY
fascicolo: 2, volume: 66, anno: 2001,
pagine: 137 - 139
SICI:
0902-4441(200102)66:2<137:TOTLWN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; GRAFT-VERSUS-LEUKEMIA; CHEMOTHERAPY; MALIGNANCIES; DISEASES; THERAPY;
Keywords:
T-prolymphocytic leukemia; leukemic meningitis; nonmyeloablative allogeneic transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Garderet, L Hop St Antoine, Serv Hematol Greffe Moella, 184 Rue Fg St Antoine, F-75571Paris 12, France Hop St Antoine 184 Rue Fg St Antoine Paris France 12 , France
Citazione:
L. Garderet et al., "Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation", EUR J HAEMA, 66(2), 2001, pp. 137-139

Abstract

Aim: T-prolymphocytic leukemia (T-PLL) is a rare disease of the elderly characterized by a high white blood cell count and organomegaly, and is currently incurable. Our aim was to elicit graft-versus-leukemia reactions in a patient with T-PLL. Methods: A 52-yr-old woman with refractory T-PLL underwent a nonmyeloablative regimen followed by allogeneic peripheral blood stemcell transplantation (a "minitransplant") from her HLA-matched sibling. Results: There was no treatment related toxicity other than neutropenia. Engraftment was successful. The patient experienced no graft-versus-host disease (GVHD) at any time but, on day 84 after transplantation, had a relapse inthe central nervous system. Despite infusion of donor lymphocytes and intralumbar chemotherapy, she died on day 157 of systemic disease. Conclusion: The reasons why treatment may have failed are discussed (nature of disease,disease progression, treatment schedule).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:45:54