Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pheochromocytoma in multiple endocrine neoplasia type 2: a prospective study
Autore:
Nguyen, L; Niccoli-Sire, P; Caron, P; Bastie, D; Maes, B; Chabrier, G; Chabre, O; Rohmer, V; Lecomte, P; Henry, JF; Conte-Devolx, B;
Indirizzi:
Hop Enfants La Timone, Serv Endocrinol, F-13385 Marseille 05, France Hop Enfants La Timone Marseille France 05 , F-13385 Marseille 05, France Hop Enfants La Timone, Serv Chirurg Endocrinienne, F-13385 Marseille, France Hop Enfants La Timone Marseille France F-13385 F-13385 Marseille, France Hop Rangueil, Serv Endocrinol, Toulouse, France Hop Rangueil Toulouse France angueil, Serv Endocrinol, Toulouse, France Inst Claudius Regaud, Ctr Reg Lutte Canc, Toulouse, France Inst Claudius Regaud Toulouse France r Reg Lutte Canc, Toulouse, France Inst Jean Godinoi, Ctr Reg Lutte Canc, F-51056 Reims, France Inst Jean Godinoi Reims France F-51056 Lutte Canc, F-51056 Reims, France Hop Hautepierre, Serv Endocrinol, Strasbourg, France Hop Hautepierre Strasbourg France , Serv Endocrinol, Strasbourg, France Hop Michallon, Serv Endocrinol, Grenoble, France Hop Michallon Grenoble France hallon, Serv Endocrinol, Grenoble, France CHU Angers, Serv Endocrinol, Angers, France CHU Angers Angers FranceCHU Angers, Serv Endocrinol, Angers, France Hop Bretonneau, Serv Endocrinol, Tours, France Hop Bretonneau Tours France Bretonneau, Serv Endocrinol, Tours, France
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 1, volume: 144, anno: 2001,
pagine: 37 - 44
SICI:
0804-4643(200101)144:1<37:PIMENT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY-THYROID CARCINOMA; PENTAGASTRIN STIMULATION TEST; RET PROTOONCOGENE MUTATIONS; ADRENAL-SPARING SURGERY; MEN 2A; HEREDITARY PHEOCHROMOCYTOMA; PLASMA METANEPHRINES; LINDAU-DISEASE; DIAGNOSIS; CALCITONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Conte-Devolx, B Hop Enfants La Timone, Serv Endocrinol, F-13385 Marseille 05, France Hop Enfants La Timone Marseille France 05 lle 05, France
Citazione:
L. Nguyen et al., "Pheochromocytoma in multiple endocrine neoplasia type 2: a prospective study", EUR J ENDOC, 144(1), 2001, pp. 37-44

Abstract

Objective: The aim of this prospective study is to update our knowledge ofthe chronology of pheochromocytoma occurrence in multiple endocrine neoplasia type 2 (MEN 2), and to better manage MEN 2 patients after the genetic diagnosis. Design: Eighty-seven non-index gene carrier MEN 2 patients were included in this prospective study: 84 patients with MEN 2A (from 52 families) and 3 with MEN 2B (from 3 families),Methods: Medullary thyroid carcinoma (MTC) was diagnosed by measuring plasma calcitonin in basal conditions or after pentagastrin stimulation. The search for pheochromocytoma consisted of clinical evaluation, 24 h determination of urinary catecholamines and adrenal imaging. The mean age at genetic diagnosis of MEN 2 was 14.0 +/- 7.0 years, the mean duration for the follow-up was;7.6 +/- 2.8 pears,Results: All 87 patients had a MTC detected at the same time as the genetic diagnosis was made. Urinary catecholamine measurements led to the diagnosis of pheochromocytoma and a combination of imaging techniques enabled the correct localization of both unilateral or bilateral adrenal involvement. Pheochromocytoma was detected simultaneously with MTC in only seven patients, and seven others were detected throughout the follow-up. Of the 14 patients with pheochromocytoma, 11 had bilateral involvement: nine were initiallybilateral and two became so during follow-up. Conclusion: This study demonstrates that in MEN 2, MTC is the lesion whichappears earliest. Pheochromocytoma develops later during the evolution of the disease, and necessitates regular clinical and biological monitoring throughout follow-up. Determination of urinary and/or plasma catecholamines and metanephrines should be performed to detect pheochromocytoma. Imaging techniques lead to the detection of both unilateral and bilateral pheochromocytoma, thus making video-assisted laparoscopic adrenalectomy possible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:24:29