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Titolo:
Killing tumour cells by alkylphosphocholines: Evidence for involvement of CD95
Autore:
Matzke, A; Massing, U; Krug, HF;
Indirizzi:
Forschungszentrum Karlsruhe, Inst Toxicol & Genet, D-76021 Karlsruhe, Germany Forschungszentrum Karlsruhe Karlsruhe Germany D-76021 Karlsruhe, Germany Tumour Biol Ctr, Freiburg, Germany Tumour Biol Ctr Freiburg GermanyTumour Biol Ctr, Freiburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF CELL BIOLOGY
fascicolo: 1, volume: 80, anno: 2001,
pagine: 1 - 10
SICI:
0171-9335(200101)80:1<1:KTCBAE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ALKYL PHOSPHOLIPID ANALOGS; HUMAN LEUKEMIC-CELLS; INDUCED APOPTOSIS; SELECTIVE DESTRUCTION; SIGNALING PATHWAYS; ANTICANCER DRUGS; FAMILY PROTEASE; HL-60 CELLS; ACTIVATION;
Keywords:
alkylphosphocholines; BCL-2; caspases; CD95; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Krug, HF Forschungszentrum Karlsruhe, Inst Toxicol & Genet, POB 3640, D-76021 Karlsruhe, Germany Forschungszentrum Karlsruhe POB 3640 Karlsruhe Germany D-76021 y
Citazione:
A. Matzke et al., "Killing tumour cells by alkylphosphocholines: Evidence for involvement of CD95", EUR J CELL, 80(1), 2001, pp. 1-10

Abstract

Many lipids act as cellular messengers and lead to a variety of different cellular responses. Out of the group of these compounds the ceramides are able to induce apoptosis, and some synthetic lipids can mimic this effect. Apoptosis is an important mechanism whereby chemotherapeutics exhibit their anti-oncogenic activity. Although, some lipid analogues were used in clinical trials, they exert severe side effects and their mechanism of action is widely unknown. We present here a new class of synthetic alkylphosphocholines (APC) that induce programmed cell death in leukaemia cells. The signs ofapoptosis arise after 1 h of incubation with these compounds as shown by phosphatidylserine externalisation followed by caspase activation and DNA fragmentation. We demonstrate that the molecular target of these lipids is upstream of caspases and Bcl-2, Experiments with FADD dominant negative cellsreveal that induction of apoptosis occurs on the level of CD95 and that these compounds can now be optimised for their capacity to activate the apoptosis-inducing receptor CD95.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:38:37