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Titolo:
beta(3)-Adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian population
Autore:
van-Dybicz, AMO; Vonkeman, HE; Bon, MAM; van den Bergh, FAJTM; Vermes, I;
Indirizzi:
Med Spectrum Twente, Dept Clin Chem, NL-7500 KA Enschede, Netherlands Med Spectrum Twente Enschede Netherlands NL-7500 KA nschede, Netherlands Med Spectrum Twente, Dept Internal Med, NL-7500 KA Enschede, Netherlands Med Spectrum Twente Enschede Netherlands NL-7500 KA nschede, Netherlands
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 1, volume: 3, anno: 2001,
pagine: 47 - 51
SICI:
1462-8902(200101)3:1<47:BRGPAT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-3-ADRENERGIC RECEPTOR; INSULIN-RESISTANCE; TRP64ARG MUTATION; GLUCOSE-TOLERANCE; MORBID-OBESITY; WEIGHT-GAIN; ASSOCIATION; MELLITUS; RISK; SYSTEM;
Keywords:
beta(3)-adrenergic receptor; non-insulin-dependent diabetes mellitus; obesity; body mass index; glycohaemoglobin; microalbuminuria; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Vermes, I Med Spectrum Twente, Dept Clin Chem, POB 50000, NL-7500 KA Enschede, Netherlands Med Spectrum Twente POB 50000 Enschede Netherlands NL-7500 KA s
Citazione:
A.M.O. van-Dybicz et al., "beta(3)-Adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian population", DIABET OB M, 3(1), 2001, pp. 47-51

Abstract

Aim: The beta (3)-adrenergic receptor (beta (3)-AR) is suspected to play akey role in the regulation of energy balance by increasing lipolysis and thermogenesis. A mutation in the beta (3)-AR gene (Trp64Arg) has been associated with the capacity of weight gain and with early onset of noninsulin dependent diabetes mellitus (type 2 diabetes). In this study we investigated the prevalence of the two beta (3)-AR alleles in a Caucasian population andstudied the association between the beta (3)-AR genotype and metabolic disorders (obesity and type 2 diabetes). Methods: Genomic DNA extracted from peripheral blood leucocytes of 200 Caucasian subjects (137 subjects with and 63 subjects without type 2 diabetes). The MvaI polymorphism of beta (3)-AR, which detects the Trp64Arg mutation, was determined by polymerase chain reaction (PCR). We studied the correlation between the Trp64Arg mutation and the body mass index (b.m.i. kg/m(2)). Results: There was no significant difference between the patients with type 2 diabetes and control subjects in the frequency of the Arg64 allele (5.5% and 4.8%, respectively). Within the group of type 2 diabetes patients were 14 subjects with the Trp64Arg mutation (b.m.i., mean +/- s.d.: 31 +/- 8.5kg/m(2)) and 123 without the mutation (b.m.i. 29 +/- 4.8). There was no association between the beta (3)-AR gene polymorphism and sex, obesity, bloodpressure, glycohaemoglobin concentration, proteinuria. Conclusion: Our results suggest that the Trp64Arg mutation is not a major determinant of metabolic disorders (type 2 diabetes, obesity) and chronic complications of type 2 diabetes in a Dutch population.

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Documento generato il 25/01/20 alle ore 16:00:35