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Titolo:
Clustering of cardiovascular risk factors in type 2 diabetes mellitus: prognostic significance and tracking
Autore:
Kaukua, J; Turpeinen, A; Uusitupa, M; Niskanen, L;
Indirizzi:
Kuopio Univ Hosp, Dept Med, FIN-70211 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70211 Med, FIN-70211 Kuopio, Finland Univ Kuopio, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 v Kuopio, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Clin Nutr, FIN-70211 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70211 utr, FIN-70211 Kuopio, Finland
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 1, volume: 3, anno: 2001,
pagine: 17 - 23
SICI:
1462-8902(200101)3:1<17:COCRFI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; NONDIABETIC SUBJECTS; FOLLOW-UP; INSULIN; MORTALITY; MEN; INTERVENTION; CHOLESTEROL;
Keywords:
type 2 diabetes mellitus; cardiovascular risk factor; clustering; tracking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Niskanen, L Kuopio Univ Hosp, Dept Med, Bldg 5,POB 1777, FIN-70211 Kuopio,Finland Kuopio Univ Hosp Bldg 5,POB 1777 Kuopio Finland FIN-70211 and
Citazione:
J. Kaukua et al., "Clustering of cardiovascular risk factors in type 2 diabetes mellitus: prognostic significance and tracking", DIABET OB M, 3(1), 2001, pp. 17-23

Abstract

Aim: Little attention has been paid to the prognostic significance and tracking effect of risk factor clusters characteristic of type 2 diabetes mellitus. We studied the clustering of eight cardiovascular risk factors (smoking, high body mass index, elevated systolic blood pressure, high serum, lowdensity lipoprotein (LDL) cholesterol, high serum LDL triglycerides, low serum, high density lipoprotein (HDL) cholesterol, high fasting blood glucose and high plasma insulin concentration) and their effect on the prognosis and the tracking effect. Methods: This study is a population-based prospective follow-up of newly diagnosed type 2 diabetic subjects (n = 133, aged 45-64 years) in Eastern Finland. The following end points were used: all-cause mortality, cardiovascular mortality, and incidences of first myocardial infarction and first stroke. Furthermore, we studied the 'tracking effect' of the risk factor clusters during the 10-year follow-up period. Results: When the clustering of risk factors typical of type 2 diabetes mellitus was taken into account, all-cause mortality increased from 28.6% to 50.0% (p < 0.05) and cardiovascular disease mortality increased from 14.3% to 50.0% (p < 0.01) depending on the number of risk factors present. The incidence of first myocardial infarction increased from 0% to 40.0% (p < 0.05) as the number of risk factors increased from 0 to 5. In survivors, the proportion of individuals with no risk factors decreased and the proportion on individuals with three to four risk factors increased during the 10-year follow-up period despite the high mortality among the group with many risk factors. Conclusions: The risk factor clusters among type 2 diabetic subjects are of great predictive value and when not aggressively treated, show a relentless increase despite selective mortality.

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Documento generato il 11/07/20 alle ore 19:49:14