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Titolo:
Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
Autore:
Espana, A; Solano, T; Quintanilla, E;
Indirizzi:
Univ Navarra, Univ Navarra Clin, Sch Med, Dept Dermatol, E-31080 Pamplona,Spain Univ Navarra Pamplona Spain E-31080 ept Dermatol, E-31080 Pamplona,Spain
Titolo Testata:
DERMATOLOGIC SURGERY
fascicolo: 1, volume: 27, anno: 2001,
pagine: 23 - 27
SICI:
1076-0512(200101)27:1<23:BITTOK>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRALESIONAL BLEOMYCIN; LYSYL OXIDASE; SKIN; WARTS; SCLERODERMA; FIBROBLASTS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Espana, A Univ Navarra, Univ Navarra Clin, Sch Med, Dept Dermatol, POB 4209, E-31080Pamplona, Spain Univ Navarra POB 4209 Pamplona Spain E-31080 080Pamplona, Spain
Citazione:
A. Espana et al., "Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures", DERM SURG, 27(1), 2001, pp. 23-27

Abstract

BACKGROUND. The treatment of keloids and hypertrophic scars has been difficult and a recent French study showed that bleomycin has been useful in thetreatment of these lesions. OBJECTIVE. To determine the effectiveness and safety of bleomycin in the treatment of hypertrophic scars and keloids when this drug is administered through multiple superficial punctures,METHODS. We applied bleomycin to keloids and hypertrophic scars in 13 patients using a multiple-puncture method on the surface of the skin. All patients were given bleomycin at a concentration of 1.5 IU/ml. Clinical responseafter treatment was classified according to the following scale: complete flattening (100%), highly significant flattening (>90%), or significant flattening (75-90%),RESULTS. The clinical response was very positive in all cases: complete flattening in six cases, highly significant flattening in six cases, and significant flattening in one case. Two patients presented a recurrence as a small nodule 10 and 12 months after the last infiltration,CONCLUSIONS. These clinical findings show that administration of bleomycinin keloids and hypertrophic scars shows promise and needs further investigation.

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Documento generato il 23/01/21 alle ore 03:41:59