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Titolo:
Gastrointestinal sparing anti-inflammatory drugs - Effects on ulcerogenic and healing responses
Autore:
Takeuchi, K; Tanaka, A; Suzuki, K; Mizoguchi, H;
Indirizzi:
Kyoto Pharmaceut Univ, Dept Pharmacol & Expt Therapeut, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 herapeut, Kyoto 6078414, Japan
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 1, volume: 7, anno: 2001,
pagine: 49 - 69
SICI:
1381-6128(200101)7:1<49:GSAD-E>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GASTRIC-MUCOSAL LESIONS; MESSENGER-RNA; IN-VITRO; CYCLOOXYGENASE-2 INHIBITORS; PROSTAGLANDIN SYNTHASE; SUPEROXIDE RADICALS; LEUKOCYTE ADHESION; CYSTEINE PROTEASES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Takeuchi, K Kyoto Pharmaceut Univ, Dept Pharmacol & Expt Therapeut, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 oto 6078414, Japan
Citazione:
K. Takeuchi et al., "Gastrointestinal sparing anti-inflammatory drugs - Effects on ulcerogenic and healing responses", CUR PHARM D, 7(1), 2001, pp. 49-69

Abstract

The use of nonsteroidal antiinflammatory drugs (NSAIDs) is associated witha wide array of alterations in gastrointestinal integrity and function. Various approaches have been taken to developing NSAIDs with reduced gastrointestinal toxicity, and few have been successfully reduced the incidence of adverse reactions. These include cyclooxygenase-2 (COX-2) selective inhibitors and nitric oxide (NO)releasing NSAIDs. Especially, much has been written about the potential of COX-2 inhibitors as antiinflammatory and analgesicagents that lack the gastrointestinal side effects of traditional NSAIDs. COX-2 expression is most evident at sites of inflammation, while COX-I accounts for the majority of prostaglandin synthesis in the normal gastrointestinal tract. However, there are distinct examples of circumstances in which COX-2-derived prostaglandins play a role in the maintenance of gastrointestinal mucosal integrity, particularly when the mucosa is injured, and the delineation of COX-1 and COX-2 might not be quite as clear as has been suggested. On the other hand, the rational behind the NO-releasing NSAIDs is thatthe NO released from the derivatives will exert beneficial effects on the gastrointestinal mucosa. This approach has been successfully demonstrated to lessen the incidence of gastrointestinal damage and to promote the healing of gastric ulcers. The present article overviews the roles of COX and NO in housekeeping functions of the gastrointestinal mucosa in various circumstances, and the effects of gastrointestinal sparing NSAIDs, mainly COX-2 selective inhibitors and NO-releasing derivatives of NSAIDs, on the ulcerogenic and healing responses in the gastrointestinal mucosa of experimental animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:45:15