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Titolo:
Kinin receptors and their antagonists as novel therapeutic agents
Autore:
Ozturk, Y;
Indirizzi:
Anadolu Univ, Dept Pharmacol, Fac Pharm, TR-26470 Eskisehir, Turkey Anadolu Univ Eskisehir Turkey TR-26470 Pharm, TR-26470 Eskisehir, Turkey
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 2, volume: 7, anno: 2001,
pagine: 135 - 161
SICI:
1381-6128(200101)7:2<135:KRATAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRADYKININ B-2 RECEPTOR; SMOOTH-MUSCLE CELLS; CONVERTING-ENZYME-INHIBITORS; NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; ISCHEMIC NOREPINEPHRINE RELEASE; EXPERIMENTAL ACUTE-PANCREATITIS; PROTEIN-COUPLED RECEPTORS; ARTERY ENDOTHELIAL-CELLS; IRIS SPHINCTER MUSCLE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
436
Recensione:
Indirizzi per estratti:
Indirizzo: Ozturk, Y Anadolu Univ, Dept Pharmacol, Fac Pharm, TR-26470 Eskisehir, Turkey Anadolu Univ Eskisehir Turkey TR-26470 26470 Eskisehir, Turkey
Citazione:
Y. Ozturk, "Kinin receptors and their antagonists as novel therapeutic agents", CUR PHARM D, 7(2), 2001, pp. 135-161

Abstract

Plasma kinins are a family of peptides which play an important role in a variety of pathophysiological conditions. As a consequence of the progress in the area of kinin receptors, specific kinin receptor antagonists will be available in near future in order to provide more selective therapeutic modalities for the treatment of diseases such as asthma, cardiovascular diseases, inflammation, pain, etc. Although the initial observation leading to dicovery of kinins has been performed in 1909, important progress on the development of specific kinin receptor antagonists has been made in last two decades. This review emphesizes the physiological functions of kinins along with their receptor subtypes and post-receptor events in the cellular signaling. In this article, the latest developments in the kinin receptor antagonists including nonpeptide ones have been reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:48:43