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Titolo:
Expression of involucrin by ocular surface epithelia of patients with benign and malignant disorders
Autore:
Saika, S; Minamide, A; Tanaka, T; Miyamoto, T; Okada, Y; Kawashima, Y; Ohnishi, Y; Ooshima, A; Kao, WWY;
Indirizzi:
Wakayama Med Coll, Dept Ophthalmol, Wakayama 6418509, Japan Wakayama Med Coll Wakayama Japan 6418509 halmol, Wakayama 6418509, Japan Wakayama Med Coll, Dept Pathol, Wakayama 6418509, Japan Wakayama Med CollWakayama Japan 6418509 Pathol, Wakayama 6418509, Japan Univ Cincinnati, Med Ctr, Dept Ophthalmol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 thalmol, Cincinnati, OH 45267 USA
Titolo Testata:
CURRENT EYE RESEARCH
fascicolo: 5, volume: 21, anno: 2000,
pagine: 877 - 885
SICI:
0271-3683(2000)21:5<877:EOIBOS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMAS; PSORIATIC EPIDERMIS; SKIN; BASAL; DIFFERENTIATION;
Keywords:
involucrin; profilaggrin/filaggrin; ocular surface; superior limbic keratoconjunctivitis; epithelial neoplasm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Saika, S Wakayama Med Coll, Dept Ophthalmol, 811-1 Kimiidera, Wakayama 6418509, Japan Wakayama Med Coll 811-1 Kimiidera Wakayama Japan 6418509 , Japan
Citazione:
S. Saika et al., "Expression of involucrin by ocular surface epithelia of patients with benign and malignant disorders", CURR EYE R, 21(5), 2000, pp. 877-885

Abstract

Purpose. Keratinization of the ocular surface epithelium is associated with various disorders impairing vision. We immunohistochemically determined whether the ocular surface epithelia express involucrin, and whether its expression pattern may differ in benign vs. malignant disorders. Expression ofcytokeratins was also examined to provide further information relative to the epithelial differentiation. Methods. We evaluated 17 specimens; 6 specimens of the normal ocular surface epithelia, 3 specimens from cases of conjunctival intraepithelial neoplasia (CIN), 6 of conjunctival squamous cell carcinoma (SCC) and 2 of conjunctivae from cases of superior limbic keratoconjunctivitis (SLK). Results. Corneal epithelium exhibited intracellular immunoreactivity for involucrin. Four of the 6 specimens of bulbar conjunctival epithelium showedinvolucrin immunoreactivity in the perimembranous region, whereas the fornical conjunctiva was negative. Cornified envelope in SLK specimens was positive for involucrin. The CIN showed its immunoreactivity in the perimembranous region in all levels of the hyperproliferative epithelium without keratinization, i.e., similar to the bulbar conjunctiva. The neoplastic cells ofwell-differentiated SCC showed involucrin in the perimembranous region, and those of moderately- to poorly-differentiated SCC have involucrin in their cytoplasm. The expression pattern of cytokeratins was unrelated to grade of malignancy in ocular SCC. Conclusion. The epithelia of normal subjects and of CIN expresses involucrin without keratinization. In contrary, the keratinized SLK epithelium markedly expresses involucrin in the cornified envelope. The subcellular immunolocalization of involucrin in the ocular SCC may help in evaluating the differentiation, i.e., malignancy, of neoplastic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:46:40