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Titolo:
Cytomegalovirus pneumonia in adults with leukemia: An emerging problem
Autore:
Nguyen, Q; Estey, E; Raad, I; Rolston, K; Kantarjian, H; Jacobson, K; Konoplev, S; Ghosh, S; Luna, M; Tarrand, J; Whimbey, E;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Internal Med Specialties, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 al Med Specialties, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Ctr, Dept Leukemia, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 c Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Microbiol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 tr, Dept Microbiol, Houston, TX 77030 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 4, volume: 32, anno: 2001,
pagine: 539 - 545
SICI:
1058-4838(20010215)32:4<539:CPIAWL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LYMPHOCYTIC-LEUKEMIA; T-CELL LEUKEMIA; HEMATOLOGICAL MALIGNANCIES; MYELODYSPLASTIC SYNDROMES; PNEUMOCYSTIS PNEUMONIA; FLUDARABINE PHOSPHATE; REMISSION INDUCTION; VIRUS INFECTIONS; LYMPHOMA; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Whimbey, E Univ Texas, MD Anderson Canc Ctr, Dept Internal Med Specialties, 1515 Holcombe Blvd,Box 47, Houston, TX 77030 USA Univ Texas 1515 HolcombeBlvd,Box 47 Houston TX USA 77030 0 USA
Citazione:
Q. Nguyen et al., "Cytomegalovirus pneumonia in adults with leukemia: An emerging problem", CLIN INF D, 32(4), 2001, pp. 539-545

Abstract

Cytomegalovirus (CMV) pneumonia is reportedly unusual among adults with leukemia who have not undergone transplantation. To assess the frequency of CMV pneumonia and its outcome during the present time, we reviewed the experience of 2136 hospitalized adults with leukemia. Sixty-one patients (2.9%) had CMV pneumonia diagnosed. The frequency doubled from 1.4% in 1992-1994 to 2.8% in 1995-1997 (P<.05). Fifty-four patients (89%) had received treatment with an immunosuppressive chemotherapeutic regimen that contained fludarabine (n = 37), high-dose cytoxan (n = 17), or both (n = 10), and 15 patients (25%) had received granulocyte transfusions that were stimulated with hematopoietic growth factors from unscreened donors. The overall CMV pneumonia-associated mortality rate was 57%. Among autopsied patients who had leukemia, the frequency of CMV pneumonia increased from 0%, 2.3%, and 0% in 1992, 1993, and 1994, respectively, to 4.6%, 6.5%, and 16% in 1995, 1996, and 1997, respectively (P<.05). CMV has emerged as an important cause of life-threatening pneumonia in adults with leukemia who have received potent immunosuppressive therapies and stimulated granulocyte transfusions from unscreened donors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:35:23