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Titolo:
Candidal vertebral osteomyelitis: Report of 6 patients, and a review
Autore:
Hendrickx, L; Van Wijngaerden, E; Samson, I; Peetermans, WE;
Indirizzi:
Univ Hosp Leuven, Dept Internal Med, B-3000 Louvain, Belgium Univ Hosp Leuven Louvain Belgium B-3000 nal Med, B-3000 Louvain, Belgium Univ Hosp Leuven, Dept Orthoped Surg, B-3000 Louvain, Belgium Univ Hosp Leuven Louvain Belgium B-3000 ed Surg, B-3000 Louvain, Belgium
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 4, volume: 32, anno: 2001,
pagine: 527 - 533
SICI:
1058-4838(20010215)32:4<527:CVORO6>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORULOPSIS-GLABRATA; ALBICANS OSTEOMYELITIS; SPINAL OSTEOMYELITIS; AMPHOTERICIN-B; NOSOCOMIAL CANDIDEMIA; SPACE INFECTION; RISK-FACTORS; FLUCONAZOLE; TROPICALIS; EPIDEMIOLOGY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Peetermans, WE Univ Hosp Leuven, Dept Internal Med, Herestr 49, B-3000 Louvain, Belgium Univ Hosp Leuven Herestr 49 Louvain Belgium B-3000 Belgium
Citazione:
L. Hendrickx et al., "Candidal vertebral osteomyelitis: Report of 6 patients, and a review", CLIN INF D, 32(4), 2001, pp. 527-533

Abstract

The incidence of deep-seated candidal infection is increasing, but candidal vertebral osteomyelitis is still rare. We describe 6 patients recently treated in our hospital. Conservative treatment failed in all. We reviewed the literature and identified 59 additional cases of candidal vertebral osteomyelitis. Candidemia was documented in 61.5% of them. The interval between the diagnosis of candidemia and the onset of symptoms of vertebral osteomyelitis varied widely, from days to >1 year. In patients without documented candidemia, there was a similar interval between the occurrence of risk factors for candidemia (present in 72% of the patients) and the onset of symptoms of vertebral osteomyelitis. Clinical, laboratory, and radiological findings are not specific for candidal spondylodiskitis. Final diagnosis is determined by means of culture of a biopsy specimen from the infected vertebra or disk. Treatment consisted of prolonged antifungal treatment, and it often included surgery. On the basis of our experience (for all 6 patients, initial conservative treatment with only antifungals failed), we recommend consideration of early surgical debridement in combination with prolonged antifungal therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:21:17