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Titolo:
Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein
Autore:
Seo, SB; McNamara, P; Heo, S; Turner, A; Lane, WS; Chakravarti, D;
Indirizzi:
Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA Harvard Univ, Harvard Microchem & Prot Facil, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 & Prot Facil, Cambridge, MA 02138 USA
Titolo Testata:
CELL
fascicolo: 1, volume: 104, anno: 2001,
pagine: 119 - 130
SICI:
0092-8674(20010112)104:1<119:ROHAAT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATING FACTOR-I; PROTEIN PHOSPHATASE 2A; ACETYLTRANSFERASE ACTIVITY; STIMULATES TRANSCRIPTION; NUCLEAR PHOSPHOPROTEIN; MYELOID LEUKEMOGENESIS; CHROMATIN STRUCTURE; PUTATIVE ONCOGENE; COACTIVATORS P300; DNA-BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Chakravarti, D Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 adelphia, PA 19104 USA
Citazione:
S.B. Seo et al., "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein", CELL, 104(1), 2001, pp. 119-130

Abstract

Acetylation of histones by p300/CBP and PCAF is considered to be a critical step in transcriptional regulation. In order to understand the role of cellular activities that modulate histone acetylation and transcription, we have purified and characterized a multiprotein cellular complex that potently inhibits the histone acetyltransferase activity of p300/CBP and PCAF. We have mapped a novel acetyltransferase-inhibitory domain of this INHAT (inhibitor of acetyltransferases) complex that binds to histones and masks them from being acetyltransferase substrates. Endogenous INHAT subunits, which include the Set/TAF-I beta oncoprotein, associate with chromatin in vivo andcan block coactivator-mediated transcription when transfected in cells. Wepropose that histone masking by INHAT plays a regulatory role in chromatinmodification and serves as a novel mechanism of transcriptional regulation.

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Documento generato il 04/07/20 alle ore 23:57:42