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Titolo:
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappa B and neural tube closure
Autore:
Ruland, J; Duncan, GS; Elia, A; Barrantes, ID; Nguyen, L; Plyte, S; Millar, DG; Bouchard, D; Wakeham, A; Ohashi, PS; Mak, TW;
Indirizzi:
Amgen Inst, Toronto, ON M5G 2C1, Canada Amgen Inst Toronto ON Canada M5G 2C1 en Inst, Toronto, ON M5G 2C1, Canada Univ Toronto, Ontario Canc Inst, Toronto, ON M5G 2C1, Canada Univ TorontoToronto ON Canada M5G 2C1 Inst, Toronto, ON M5G 2C1, Canada Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada Univ Toronto Toronto ON Canada M5G 2C1 ophys, Toronto, ON M5G 2C1, Canada Univ Toronto, Dept Immunol, Toronto, ON M5G 2C1, Canada Univ Toronto Toronto ON Canada M5G 2C1 munol, Toronto, ON M5G 2C1, Canada
Titolo Testata:
CELL
fascicolo: 1, volume: 104, anno: 2001,
pagine: 33 - 42
SICI:
0092-8674(20010112)104:1<33:BIAPRO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CASPASE RECRUITMENT DOMAIN; T-CELL; LYMPHOCYTE-PROLIFERATION; DEFICIENT LYMPHOCYTES; TRANSCRIPTION FACTOR; CONTAINING PROTEIN; DEATH RECEPTORS; MICE LACKING; IN-VIVO; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Mak, TW Amgen Inst, 620 Univ Ave, Toronto, ON M5G 2C1, Canada Amgen Inst 620 Univ Ave Toronto ON Canada M5G 2C1 M5G 2C1, Canada
Citazione:
J. Ruland et al., "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappa B and neural tube closure", CELL, 104(1), 2001, pp. 33-42

Abstract

Bcl10, a CARD-containing protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas, has been shown to induce apoptosis and activate NF-kappaB in vitro. We show that one-third of bcl10(-/-) embryos developed exencephaly, leading to embryonic lethality. Surprisingly, bcl10(-/-) cells retained susceptibility to various apoptotic stimuli in vivo and in vitro. However, surviving bcl10(-/-) mice were severely immunodeficient and bcl10(-/-) lymphocytes are defective in antigen receptor or PMA/lonomycin-inducedactivation. Early tyrosine phosphorylation, MAPK and AP-1 activation, and Ca2+ signaling were normal in mutant lymphocytes, but antigen receptor-induced NF-kappaB activation was absent. Thus, Bcl10 functions as a positive regulator of lymphocyte proliferation that specifically connects antigen receptor signaling in B and T cells to NF-kappaB activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 04:21:27