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Titolo:
Vitamins C and E attenuate plasminogen activator inhibitor-1 (PAI-1) expression in a hypercholesterolemic porcine model of angioplasty
Autore:
Orbe, J; Rodriguez, JA; Calvo, A; Grau, A; Belzunce, MS; Martinez-Caro, D; Paramo, JA;
Indirizzi:
Univ Navarra, Sch Med, Lab Atherosclerosis Res, E-31080 Pamplona, Spain Univ Navarra Pamplona Spain E-31080 lerosis Res, E-31080 Pamplona, Spain Univ Navarra, Sch Med, Dept Cardiol, E-31080 Pamplona, Spain Univ NavarraPamplona Spain E-31080 ept Cardiol, E-31080 Pamplona, Spain Univ Navarra, Sch Med, Dept Histol, E-31080 Pamplona, Spain Univ Navarra Pamplona Spain E-31080 Dept Histol, E-31080 Pamplona, Spain
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 2, volume: 49, anno: 2001,
pagine: 484 - 492
SICI:
0008-6363(200102)49:2<484:VCAEAP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROTIC PLAQUE; BALLOON ANGIOPLASTY; CORONARY-ARTERIES; GENE-EXPRESSION; RESTENOSIS; INJURY; SYSTEM; MICE; TYPE-1; LDL;
Keywords:
atherosclerosis; cholesterol; angioplasty; hemostasis; restenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Paramo, JA Clin Univ, Serv Hematol, C Pio XII S-N, Pamplona 31008, Spain Clin Univ C Pio XII S-N Pamplona Spain 31008 lona 31008, Spain
Citazione:
J. Orbe et al., "Vitamins C and E attenuate plasminogen activator inhibitor-1 (PAI-1) expression in a hypercholesterolemic porcine model of angioplasty", CARDIO RES, 49(2), 2001, pp. 484-492

Abstract

Background: The plasminogen activator inhibitor-1 (PAI-1), which modulatesfibrinolysis and cell migration, may influence proteolysis and neointimal formation in the arterial wall contributing to restenosis after vascular injury. Antioxidants have been proposed as inhibiting multiple proatherogenicevents. We explore the effect of vitamins C and E on PAI-1 expression in an experimental model of angioplasty in hypercholesterolemic pigs. Methods and results: A total of 44 Yucatan minipigs were divided into three diet groups: a normal-cholesterol (NC), a high-cholesterol (HC), and a high-cholesterol plus vitamins C+E (HCV) group. Balloon injury was induced in the rightinternal iliac artery 4 weeks after initiation of either dietary regimen, and plasma and tissue samples were taken at different time periods to measure PAI-1 activity and vascular inhibitor expression. The cholesterol-rich diet induced an increased in vascular PAI-1 expression in the intima, media and adventitia which was markedly reduced in the HCV group. After injury, severe structural changes were observed in NC and HC animals associated withincreased systemic PAT-1 activity (P<0.001) and local PAT-1 expression being more intense in HC group. Vitamins C and E significantly reduced plasma PAI-1 activity (P=0.018) and attenuated the inhibitor expression as compared with HC. Conclusions: This experimental study in a porcine model of hypercholesterolemia demonstrates that vitamins C and E reduce local and systemic PAI-1 induced after angioplasty as well as the hyperchoresterolemia-induced vascular PAT-1. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/01/20 alle ore 18:35:55