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Titolo:
Photoangioplasty with local motexafin lutetium delivery reduces macrophages in a rabbit post-balloon injury model
Autore:
Hayase, M; Woodbum, KW; Perlroth, J; Miller, RA; Baumgardner, W; Yock, PG; Yeung, A;
Indirizzi:
Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ardiovasc Med, Stanford, CA 94305 USA Toyohashi Heart Ctr, Toyohashi, Aichi, Japan Toyohashi Heart Ctr Toyohashi Aichi Japan t Ctr, Toyohashi, Aichi, Japan Pharmacycl Inc, Sunnyvale, CA USA Pharmacycl Inc Sunnyvale CA USAPharmacycl Inc, Sunnyvale, CA USA
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 2, volume: 49, anno: 2001,
pagine: 449 - 455
SICI:
0008-6363(200102)49:2<449:PWLMLD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY ATHEROSCLEROTIC PLAQUES; INTRAVASCULAR ULTRASOUND; PHOTODYNAMIC THERAPY; TEXAPHYRIN PCI-0123; ATHEROMATOUS PLAQUE; STENT IMPLANTATION; RESTENOSIS; ATHEROGENESIS; INFILTRATION; ANGIOPLASTY;
Keywords:
angioplasty; arteries; atherosclerosis; macrophages; restenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Yeung, A Stanford Univ, Sch Med, Div Cardiovasc Med, 300 Pasteur Dr, Stanford, CA 94305 USA Stanford Univ 300 Pasteur Dr Stanford CA USA 94305 , CA 94305 USA
Citazione:
M. Hayase et al., "Photoangioplasty with local motexafin lutetium delivery reduces macrophages in a rabbit post-balloon injury model", CARDIO RES, 49(2), 2001, pp. 449-455

Abstract

Objective: Motexafin lutetium (Lu-Tex, Antrin(R) Injection) is a photosensitizer that selectively accumulates in atheromatous plaque where it can be activated by far-red light. The localization and retention of intra-arterially administered Lu-Tex and its efficacy following activation by endovascularly delivered Light (photoangioplasty) was evaluated. Methods: Bilateral iliac artery lesions were induced in 17 rabbits by balloon denudation, followed by a high cholesterol diet. Lu-Tex distribution within the atheroma wasexamined (n=8) following local injection. Fluorescence spectral imaging and chemical extraction techniques were used to measure Lu-Tex levels within the atheroma and adjacent normal tissue. Photoactivation was performed 15 min following Lu-Tex administration (180 J/cm fiber at 200 mW/cm fiber). Twoweeks post photoangioplasty, vessels were harvested and hematoxylin and eosin (H&E) and RAM11 (macrophages) staining was performed. Results: Local delivery of Lu-Tex achieved immediate high concentrations within plaque (mean40X control iliac atheroma). Mean percent plaque area in the treated segments was significantly lower than in the non-treated contralateral lesions (73 vs. 82%, P<0.01). No medial damage was observed. Quantitative analysis using RAM11 positive cells revealed significant reduction of macrophages in treated lesions in both the intima (5 vs. 22%, P<0.01) and in media (8 vs. 23%, P<0.01) compared to untreated contralateral segments. Conclusions: Local delivery provides high levels of Lu-Tex selectively within atheroma. Photoactivation results in a significant decrease in macrophage and a small decrease in atheroma burden without damage to the normal vessel wall. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:05:44