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Titolo:
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) fin the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model
Autore:
Frandsen, TL; Holst-Hansen, C; Nielsen, BS; Christensen, IJ; Nyengaard, JR; Carmeliet, P; Brunner, N;
Indirizzi:
Univ Copenhagen Hosp, Finsen Lab, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Aarhus Univ, Stereol Res Lab, Bartholin Bygningen, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C tholin Bygningen, DK-8000 Aarhus C, Denmark Catholic Univ Louvain, Flanders Interuniv Inst Biotechnol, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium Catholic Univ Louvain Louvain Belgium B-3000 py, B-3000 Louvain, Belgium
Titolo Testata:
CANCER RESEARCH
fascicolo: 2, volume: 61, anno: 2001,
pagine: 532 - 537
SICI:
0008-5472(20010115)61:2<532:DEOTIO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-BOUND UROKINASE; TUMOR-GROWTH; IN-VIVO; ENDOTHELIAL-CELLS; VASCULAR INJURY; MESSENGER-RNAS; MICE; TISSUE; KERATINOCYTES; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Brunner, N Univ Copenhagen Hosp, Finsen Lab, Strandboulevarden 49,Blvd 86-2, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Strandboulevarden 49,Blvd 86-2 Copenhagen Denmark DK-2100
Citazione:
T.L. Frandsen et al., "Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) fin the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model", CANCER RES, 61(2), 2001, pp. 532-537

Abstract

Several studies have indicated an interaction between tumor cells and infiltrating stromal cells regarding the urokinase plasminogen activation (uPA)system, By developing combined uPA gene-disrupted and immunodeficient mice, we have studied the role of stromal uPA for the growth of the MDA-MB-435 BAG human tumor xenograft, Subcutaneous tumor growth and lung metastasis were compared between wild-type immunodeficient mice and mice with the combined deficiencies. Tumor growth was evaluated by volume measurements and plasma P-galactosidase activity and metastasis was evaluated by counting lung surface metastases, Although no differences appeared in primary tumor take between the two groups of mice, a significant difference was observed in primary tumor growth, with tumors in uPA(-/-) mice growing significantly more slowly. In addition, a nonsignificant trend toward fewer lung metastases inuPA(-/-) mice was observed, The present data points to a critical role of stromal-derived uPA in the primary tumor growth of MDA-MB-435 BAG xenografts, whereas only a trend toward fewer lung metastases in uPA gene-disrupted mice was found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:05:24