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Titolo:
Persistent genetic instability in cancer cells induced by non-DNA-damagingstress exposures
Autore:
Li, CY; Little, JB; Hu, K; Zhang, W; Zhang, L; Dewhirst, MW; Huang, Q;
Indirizzi:
Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 tr, Dept Radiat Oncol, Durham, NC 27710 USA Harvard Univ, Sch Publ Hlth, Dept Canc Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Canc Biol, Boston, MA 02115 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 2, volume: 61, anno: 2001,
pagine: 428 - 432
SICI:
0008-5472(20010115)61:2<428:PGIICC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED GENOMIC INSTABILITY; CHROMOSOMAL INSTABILITY; MUTATOR PHENOTYPE; X-RAYS; MUTATIONS; CARCINOGENESIS; IRRADIATION; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Li, CY Duke Univ, Med Ctr, Dept Radiat Oncol, Box 3455, Durham, NC 27710 USA Duke Univ Box 3455 Durham NC USA 27710 x 3455, Durham, NC 27710 USA
Citazione:
C.Y. Li et al., "Persistent genetic instability in cancer cells induced by non-DNA-damagingstress exposures", CANCER RES, 61(2), 2001, pp. 428-432

Abstract

A hallmark of cancer cells Is their pronounced genetic instability, which has been implicated in both tumor development and negative treatment outcomes. Recently, it has been reported that ionizing radiation may induce a persistent state of hypermutability in mammalian cells that lasts for many (>30) cell divisions. In this study, we examined whether other stress signals (both DNA-damaging non-DNA-damaging) can initiate a similar process. We show that persistent genetic instability was induced by nongenotoxic stress exposures such as heat treatment, serum starvation, or the tumor microenvironment, as well as genotoxic stresses such as ionizing radiation and exposureto hydrogen peroxide. Progeny of 10-20% of surviving cells exhibited persistent and pronounced genetic instability at both an artificially transfected gene and a genomic minisatellite locus 23 cell divisions after the initial exposure. Stress-induced persistent genetic instability may be a general response of tumor cells to a wide range of genotoxic or nongenotoxic stressconditions.

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Documento generato il 22/09/20 alle ore 23:22:01