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Titolo:
Effects of a histamine type 2 receptor antagonist, BMY 26539-01, on equinegastric acid secretion
Autore:
Orsini, JA; Spencer, PA;
Indirizzi:
Univ Penn, New Bolton Ctr, Sch Vet Med, Dept Clin Studies, Kennett Square,PA 19348 USA Univ Penn Kennett Square PA USA 19348 tudies, Kennett Square,PA 19348 USA
Titolo Testata:
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
fascicolo: 1, volume: 65, anno: 2001,
pagine: 55 - 59
SICI:
0830-9000(200101)65:1<55:EOAHT2>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORSES; ULCERATION; RANITIDINE; PONIES; ULCERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Orsini, JA Univ Penn, New Bolton Ctr, Sch Vet Med, Dept Clin Studies, 382 West St Rd,Kennett Square, PA 19348 USA Univ Penn 382 West St Rd Kennett Square PA USA 19348 19348 USA
Citazione:
J.A. Orsini e P.A. Spencer, "Effects of a histamine type 2 receptor antagonist, BMY 26539-01, on equinegastric acid secretion", CAN J VET R, 65(1), 2001, pp. 55-59

Abstract

A dose-response study was undertaken of the effects of a newly developed histamine type 2 receptor antagonist, BMY-26539-01, on gastric acid secretion in 4 fasted horses. Doses of 0.1 mg/kg, 0.3 mg/kg, 0.5 mg/kg, or placebo were administered in a randomly assigned treatment sequence. Hydrogen ion concentration and pH were variable during baseline measurements in all 4 animals; however, following BMY-26539-01 administration, mean pH increased andhydrogen ion concentration decreased in a dose-related pattern. At the 0.3mg/kg and 0.5 mg/kg dose levels, pH remained elevated for > 4 h and > 8 h,respectively. No adverse effects were observed. A significant level of 0.01 was used for all statistical methods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:09:59