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Titolo:
Co-prescribing of SSRIs and TCAs in Australia: how often does it occur andwho is doing it?
Autore:
McManus, P; Mant, A; Mitchell, P; Birkett, D; Dudley, J;
Indirizzi:
Dept Hlth & Aged Care, Drug Utilizat Subcomm, Canberra, ACT, Australia Dept Hlth & Aged Care Canberra ACT Australia m, Canberra, ACT, Australia Univ New S Wales, Sch Community Med, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia munity Med, Sydney, NSW, Australia Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia h Psychiat, Sydney, NSW, Australia Flinders Med Ctr, Dept Clin Pharmacol, Adelaide, SA, Australia Flinders Med Ctr Adelaide SA Australia harmacol, Adelaide, SA, Australia
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 1, volume: 51, anno: 2001,
pagine: 93 - 98
SICI:
0306-5251(200101)51:1<93:COSATI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; COMBINATION TREATMENT; RESISTANT DEPRESSION; ANTIDEPRESSANT; FLUOXETINE; THERAPY; DRUGS;
Keywords:
coprescribing; drug utilization; selective serotonin re-uptake inhibitors; tricyclic antidepressants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: McManus, P Dept Hlth & Aged Care, Drug Utilizat Subcomm, Canberra, ACT, Australia Dept Hlth & Aged Care Canberra ACT Australia , ACT, Australia
Citazione:
P. McManus et al., "Co-prescribing of SSRIs and TCAs in Australia: how often does it occur andwho is doing it?", BR J CL PH, 51(1), 2001, pp. 93-98

Abstract

Aims To determine the frequency with which the selective serotonin re-uptake inhibitor (SSRI) antidepressants are used as add-on therapy to the tricyclic antidepressants (TCA) rather than as replacement therapy. Methods The data analysed were profiles of prescription records by date ofsupply to the patient. From within the national administrative dispensing claims database, the subset eligible for social security entitlements was identified as individuals by means of their coded permanent identification numbers (PINs). Following the initial supply of an SSRI in January 1996, thesubsequent 6 months dispensing of SSRI and TCA antidepressants to these individuals was examined. The main outcome measure was the proportion of individuals to whom SSRIs and TCAs were dispensed concurrently, as an indirect measure of coprescription. In instances where a patient was receiving prescriptions for SSRIs and TCAs that had been written by the one doctor only, the major specialty of the doctor was investigated. Results 55 271 PINs were dispensed 63 865 SSRI prescriptions in January 1996 which represented over half (52%) of the total community SSRI prescriptions dispensed in chat month. The number of these patients meeting the criteria for coprescription of SSRIs and TCAs over the next 6 months was 2773 (5%). The coprescribing instances were highest in Queensland and the prescribers most frequently involved had psychiatry major specialty codes. Conclusions Among SSRI users there is a cohort of patients who, within thesame time frame, are receiving supplies of a TCA, the nonselective drug that the SSRIs were designed to replace. This is indirect evidence of probable coprescription. Such combination use is of uncertain clinical and cost effectiveness, and carries additional risks. The SSRIs were included on the subsidy list in Australia on the basis of reasonable cost effectiveness as monotherapy compared with the TCAs. Our data imply that for some patients, antidepressant prescribing is inconsistent with the basis on which government subsidy was approved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/02/20 alle ore 16:20:41