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Titolo:
Surprises from Drosophila: Genetic mechanisms of synaptic development and plasticity
Autore:
Featherstone, DE; Broadie, K;
Indirizzi:
Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Biol, Salt Lake City, UT 84112 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 5, volume: 53, anno: 2000,
pagine: 501 - 511
SICI:
0361-9230(20001115)53:5<501:SFDGMO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; ORIGIN RECOGNITION COMPLEX; PRESYNAPTIC TRANSMITTER RELEASE; LARVAL NEUROMUSCULAR-JUNCTION; CELL-ADHESION MOLECULES; TUMOR-SUPPRESSOR GENE; GLUTAMATE RECEPTORS; FUNCTIONAL COMPONENTS; TARGET RECOGNITION; NERVOUS-SYSTEM;
Keywords:
Drosophila; neuromuscular junction; synaptogenesis; glutamate decarboxylase; latheo;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Featherstone, DE Univ Utah, Dept Biol, 257 South 1400 East, Salt Lake City, UT 84112 USA Univ Utah 257 South 1400 East Salt Lake City UT USA 84112
Citazione:
D.E. Featherstone e K. Broadie, "Surprises from Drosophila: Genetic mechanisms of synaptic development and plasticity", BRAIN RES B, 53(5), 2000, pp. 501-511

Abstract

Drosophila are excellent models for the study of synaptic development and plasticity, thanks to the availability and applicability of a wide variety of powerful molecular, genetic, and cell-biology techniques. Three decades of study have led to an intimate understanding of the sequence of events leading to a functional and plastic synapse, yet many of the molecular mechanisms underlying these events are still poorly understood. Here, we provide a review of synaptogenesis at the Drosophila glutamatergic neuromuscular junction (NMJ), Next, we discuss the role of two proteins that forward genetic screens in Drosophila have revealed to play crucial-and completely unexpected-roles in NMJ development and plasticity: the origin of replication complex protein Latheo, and the enzyme glutamate decarboxylase. The requirement for these proteins at the NMJ highlights the fact that synaptic development and plasticity involves intense inter- and intracellular signaling aboutwhich we know almost nothing. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:31:25