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Titolo:
The regulation of NMDA-evoked dopamine release by nitric oxide in the frontal cortex and raphe nuclei of the freely moving rat
Autore:
Smith, JCE; Whitton, PS;
Indirizzi:
Sch Pharm, Dept Pharmacol, London WC1N 1AX, England Sch Pharm London England WC1N 1AX pt Pharmacol, London WC1N 1AX, England
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 889, anno: 2001,
pagine: 57 - 62
SICI:
0006-8993(20010119)889:1-2<57:TRONDR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; IN-VIVO; GLUTAMATERGIC CONTROL; STRIATAL DOPAMINE; 7-NITRO INDAZOLE; SUBSTANTIA-NIGRA; CEREBRAL-CORTEX; NERVE-TERMINALS; SYNTHASE; INVIVO;
Keywords:
NMDA receptor; nitric oxide; frontal cortex; raphe nuclei; intracerebral dialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, JCE Sch Pharm, Dept Pharmacol, 29-39 Brunswick Sq, London WC1N 1AX,England Sch Pharm 29-39 Brunswick Sq London England WC1N 1AX , England
Citazione:
J.C.E. Smith e P.S. Whitton, "The regulation of NMDA-evoked dopamine release by nitric oxide in the frontal cortex and raphe nuclei of the freely moving rat", BRAIN RES, 889(1-2), 2001, pp. 57-62

Abstract

The role of nitric oxide (NO) in the N-methyl-D-aspartate (NMDA)-regulatedrelease of dopamine (DA) in the frontal cortex and raphe nuclei of the freely moving rat was measured using in vivo microdialysis. The effects of infusing the NMDA antagonist 2-amino-5-phosphonopentanoic acid (4P5; 100 muM),neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7NI; 1 mM) or the nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP; 500 muM-5 mM) were studied. The infusion of NMDA caused a significant decrease in DA levels in both regions and these effects were reversed by AF5. AP5 alone was seen to increase DA, indicating that NMDA receptors tonically regulate DA release in these brain regions. 7NI also increased extracellular DA levels when administered alone and reversed the effects of NMDA in both regions. The NO donor SNAP (500 muM-1 mM) caused a dose-dependent decrease in extracellular DA in the RN. However in the frontal cortex the highest concentration of SNAP caused extracellular dopamine to increase. These results: suggest that the regulation of NMDA-evoked DA release by NO occurs in both of the brain regions studied, although the manner in which the regulation occurs seems to differ between the two. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:36:06