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Titolo:
Increased soluble P-selectin in patients with haematological and breast cancer: a comparison with fibrinogen, plasminogen activator inhibitor and vonWillebrand factor
Autore:
Blann, AD; Gurney, D; Wadley, M; Bareford, D; Stonelake, P; Lip, GYH;
Indirizzi:
Univ Birmingham, City Hosp, Dept Med, Haemostasis Thrombosis & Vasc Biol Unit, Birmingham B18 7QH, W Midlands, England Univ Birmingham Birmingham W Midlands England B18 7QH W Midlands, England City Hosp, Dept Surg, Birmingham, W Midlands, England City Hosp Birmingham W Midlands England Birmingham, W Midlands, England City Hosp, Dept Haematol & Blood Transfus, Birmingham, W Midlands, EnglandCity Hosp Birmingham W Midlands England Birmingham, W Midlands, England
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 1, volume: 12, anno: 2001,
pagine: 43 - 50
SICI:
0957-5235(200101)12:1<43:ISPIPW>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRETREATMENT PLASMA-LEVELS; FIBRINOPEPTIDE-A FPA; D-DIMER DD; ADHESION MOLECULES; MYELOGENOUS LEUKEMIA; CELL-ADHESION; FACTOR VWF; IN-VIVO; PLATELETS; EXPRESSION;
Keywords:
soluble P-selectin; cancer; plasminogen activator inhibitor-1; von Willebrand factor; fibrinogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Blann, AD Univ Birmingham, City Hosp, Dept Med, Haemostasis Thrombosis & Vasc Biol Unit, Birmingham B18 7QH, W Midlands, England Univ Birmingham Birmingham W Midlands England B18 7QH , England
Citazione:
A.D. Blann et al., "Increased soluble P-selectin in patients with haematological and breast cancer: a comparison with fibrinogen, plasminogen activator inhibitor and vonWillebrand factor", BL COAG FIB, 12(1), 2001, pp. 43-50

Abstract

Abnormal platelet activation and an increased risk of thrombosis are frequent findings in cancer. As soluble adhesion molecule P-selectin is being increasingly recognized as reflecting increased platelet activation, we hypothesized raised levels in patients with cancer, obtaining plasma from 24 patients with a cross-section of haematological cancers, 41 with breast cancer, and from an equal number of healthy controls for each patient group. Levels of soluble P-selectin were compared with those of von Willebrand factor (vWf), plasminogen activator inhibitor-1 (PAI-1) activity and fibrinogen (markers of endothelial integrity, fibrinolysis and coagulation, respectively). We found raised soluble P-selectin, fibrinogen and vWf in both patient groups compared with their controls (P < 0.01). vWf and soluble P-selectin were higher in the haematological cancers than in breast cancer patients (by30 and 74%, respectively; both P < 0.01). There was no significant difference in levels of PAI-1 between any group. There were no differences in soluble P-selectin or vWf when the data from the women with breast cancer were classified according to tumour size, lymph node involvement or presence of vascular invasion. We conclude that the platelet marker soluble P-selectin is raised in both haematological and breast cancer, and is higher in the former, but is unrelated to the type or stage of breast cancer. Blood Coagul Fibrinolysis 12:43-50 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:52:15