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Titolo:
Elevated levels of free tissue factor pathway inhibitor antigen in cases of disseminated intravascular coagulation caused by various underlying diseases
Autore:
Asakura, H; Ontachi, Y; Mizutani, T; Kato, M; Saito, M; Morishita, E; Yamazaki, M; Suga, Y; Takami, A; Miyamoto, K; Nakao, S;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 3, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Kanazawa Univ, Sch Med, Hosp Pharm, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 1, volume: 12, anno: 2001,
pagine: 1 - 8
SICI:
0957-5235(200101)12:1<1:ELOFTF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER-PATIENTS; PLASMA-LEVELS; THROMBIN; THROMBOMODULIN; ANTICOAGULANT; LEUKEMIA; COMPLEX; DOMAINS; RELEASE; TFPI;
Keywords:
disseminated intravascular coagulation; tissue factor pathway inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Asakura, H Kanazawa Univ, Sch Med, Dept Internal Med 3, Takaramachi 13-1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Takaramachi 13-1 Kanazawa Ishikawa Japan 9208641
Citazione:
H. Asakura et al., "Elevated levels of free tissue factor pathway inhibitor antigen in cases of disseminated intravascular coagulation caused by various underlying diseases", BL COAG FIB, 12(1), 2001, pp. 1-8

Abstract

Tissue factor pathway inhibitor (TFPI) is primarily synthesized by vascular endothelial cells and is found in vivo in association with endothelial cells, lipoproteins, or in free form. Free TFPI is the most potent and important type, because it is released from endothelial cells following an injection of heparin, or as a result of pathological stimuli. In order to study the role of TFPI in disease, the concentration of free form TFPI was measured in the plasma of 114 patients suffering from disseminated intravascular coagulation (DIC), as the result of several underlying diseases. Plasma antigen levels of free TFPI were significantly higher even in those patients not exhibiting DIC than in normal healthy subjects. These levels were even higher among patients exhibiting DIG, especially those with acute promyelocytic leukemia or cancer, receiving continuous heparin drip infusions, A significant correlation was observed between the plasma antigen levels of free form TFPI and those of fibrin/fibrinogen degradation products, and free formTFPI and plasmin inhibitor complex (r= 0.428, P < 0.0001 and r= 0.329, P <0.0001, respectively) among 114 DIC patients. There were no significant differences between the plasma levels of free TFPI in DIC patients with or without multiple organ failure. It has been suggested that the plasma levels of free TFPI are closely related to the levels of fibrinolysis occurring inDIC patients, although further study is required to clarify the degree to which TFPI is expressed by endothelial cells during DIG. Blood Coagul Fibrinolysis 12:1-8 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 02/10/20 alle ore 01:28:51