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Titolo:
Enterostatin (VPDPR) has anti-analgesic and anti-amnesic activities
Autore:
Takenaka, Y; Nakamura, F; Jinsmaa, Y; Lipkowski, AW; Yoshikawa, M;
Indirizzi:
Kyoto Univ, Food Sci Res Inst, Kyoto 6110011, Japan Kyoto Univ Kyoto Japan 6110011 , Food Sci Res Inst, Kyoto 6110011, Japan Polish Acad Sci, Med Res Ctr, Warsaw, Poland Polish Acad Sci Warsaw Poland ish Acad Sci, Med Res Ctr, Warsaw, Poland
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 1, volume: 65, anno: 2001,
pagine: 236 - 238
SICI:
0916-8451(200101)65:1<236:E(HAAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION PEPTIDE; RATS; RECEPTORS; MEMORY; FAT;
Keywords:
enterostatin; anti-analgesia; anti-amnesia; anti-opioid; mu-receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshikawa, M Kyoto Univ, Food Sci Res Inst, Kyoto 6110011, Japan Kyoto Univ Kyoto Japan 6110011 s Inst, Kyoto 6110011, Japan
Citazione:
Y. Takenaka et al., "Enterostatin (VPDPR) has anti-analgesic and anti-amnesic activities", BIOS BIOT B, 65(1), 2001, pp. 236-238

Abstract

Enterostatin (VPDPR), an anorexigenic peptide derived from the amino terminus of procolipase, significantly inhibited analgesia induced by the mu -opioid agonist morphine (5 mg/kg, s,c.) after i,c,v, administration to mice at a dose of 100 nmol. On the other hand, VPDPR (similar to 200 nmol, i,c,v.) did not attenuate analgesia induced by the K-opioid agonist D-Phe-D-Phe-D-Nle-D-Arg-NH2, (100 mug/mouse, i,c,v.) or delta -opioid agonist DTLET (4 nmol/mouse, i,c,v,), VPDPR (100 nmol, i,c,v,) significantly improved amnesiainduced by scopolamine (0.2 mg/kg, i.p.) in mice. However, VPDPR did not enhance memory in normal mice at the same dose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:03:06