Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
High-dose therapy and autologous hematopoietic cell transplantation in children with primary refractory and relapsed Hodgkin's disease: Atopy predicts idiopathic diffuse lung injury syndromes
Autore:
Frankovich, J; Donaldson, SS; Lee, YB; Wong, RM; Amylon, M; Verneris, MR;
Indirizzi:
Stanford Univ, Sch Med, Div Pediat Hematol Oncol Bone Marrow Transplantat,Med Ctr, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 antat,Med Ctr, Stanford, CA 94305 USA Stanford Univ, Dept Radiat Oncol, Med Ctr, Stanford, CA 94305 USA StanfordUniv Stanford CA USA 94305 ncol, Med Ctr, Stanford, CA 94305 USA Stanford Univ, Dept Hlth Res & Policy, Med Ctr, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 licy, Med Ctr, Stanford, CA 94305 USA
Titolo Testata:
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
fascicolo: 1, volume: 7, anno: 2001,
pagine: 49 - 57
SICI:
1083-8791(2001)7:1<49:HTAAHC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; COLONY-STIMULATING FACTOR; INVOLVED-FIELD RADIOTHERAPY; TOTAL-BODY IRRADIATION; INTERSTITIAL PNEUMONITIS; ALVEOLAR HEMORRHAGE; INTERLEUKIN-13; CHEMOTHERAPY; RESPONSES; CYCLOPHOSPHAMIDE;
Keywords:
Hodgkin's disease; bone marrow transplantation; idiopathic diffuse lung injury syndrome; interstitial pneumonitis; atopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Verneris, MR Stanford Univ, Sch Med, Div Pediat Hematol Oncol Bone Marrow Transplantat,Med Ctr, 300 Pasteur Dr, Stanford, CA 94305 USA Stanford Univ 300 Pasteur Dr Stanford CA USA 94305 94305 USA
Citazione:
J. Frankovich et al., "High-dose therapy and autologous hematopoietic cell transplantation in children with primary refractory and relapsed Hodgkin's disease: Atopy predicts idiopathic diffuse lung injury syndromes", BIOL BLOOD, 7(1), 2001, pp. 49-57

Abstract

The use of high-dose therapy (HDT) and autologous hematopoietic cell transplantation (AHCT) for children and adolescents with primary refractory and relapsed Hodgkin's disease is increasing. The purpose of this retrospectiveanalysis was to: (1) evaluate the outcome of HDT and AHCT in pediatric patients with Hodgkin's disease, and (2) identify factors that predispose patients to the development of transplantation-related complications. We describe the experiences of 34 pediatric patients from a single institution with primary refractory or relapsed Hodgkin's disease. HDT regimens consisted ofcyclophosphamide and etoposide combined with either carmustine, chloroethylcyclohexylnitrosurea, or fractionated total body irradiation. Kaplan-Meiersurvival predicts that 67% (95% confidence interval [CI] 47%-87%) of patients will be alive and disease-free at 5 years. Nine patients had disease recurrence, of whom 5 relapsed after 1 year (1.5-6.3 years). Five patients succumbed to treatment-related toxicities, of whom 4 died of pulmonary failure. Fifteen patients (44%) developed post-AHCT idiopathic diffuse lung injury syndrome: acute alveoliris (n = 2); diffuse alveolar hemorrhage (n = 2); acute respiratory distress syndrome (n = 2); delayed interstitial pneumonitis (n = 8); and bronchiolitis obliterans (n = 1). The following factors didnot predict for the development of a diffuse lung injury syndrome in univariate analysis: prior treatment with bleomycin, pre-HDT pulmonary function tests, and prior thoracic irradiation. Of the patients in our cohort, 44% had a history of atopy (allergic rhinitis and/or asthma). Multivariate logistic analysis revealed that a preexisting history of atopy was highly predictive of idiopathic pulmonary complications (P = .0001, odds ratio = 21, CI 3.6-125), Our experience shows that HDT followed by AHCT results in durableremissions in two thirds of pediatric patients with refractory and relapsed Hodgkin's disease, and a history of atopy is associated with post-AHCT pulmonary complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:22:15