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Titolo:
Effects of Ninjin-to on levels of brain-gut peptides (motilin, vasoactive intestinal peptide, gastrin, and somatostatin) in human plasma
Autore:
Naito, T; Itoh, H; Nagano, T; Takeyama, M;
Indirizzi:
Oita Med Univ, Dept Clin Pharm, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 v, Dept Clin Pharm, Oita 8795593, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 2, volume: 24, anno: 2001,
pagine: 194 - 196
SICI:
0918-6158(200102)24:2<194:EONOLO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIGRATING MOTOR COMPLEX; ENZYME-IMMUNOASSAY; IMMUNOREACTIVE SUBSTANCE; INHIBITORY NEURONS; BOVINE-MILK; NEUROTRANSMITTER; POLYPEPTIDE; SCLERODERMA; OCTREOTIDE;
Keywords:
Ninjin-to; motilin; somatostatin; vasoactive intestinal peptide; gastrin; Kampo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Naito, T Oita Med Univ, Dept Clin Pharm, Hasama Machi, Oita 8795593, JapanOita Med Univ Hasama Machi Oita Japan 8795593 ita 8795593, Japan
Citazione:
T. Naito et al., "Effects of Ninjin-to on levels of brain-gut peptides (motilin, vasoactive intestinal peptide, gastrin, and somatostatin) in human plasma", BIOL PHAR B, 24(2), 2001, pp. 194-196

Abstract

We examined the effects of Ninjin-to, a traditional Chinese (Kampo) medicine, on the levels of brain-gut peptides (motilin, vasoactive intestinal peptide (VIP), gastrin, and somatostatin) in plasma from healthy subjects. A single oral administration of Ninjin-to, at a dose of 6.0 g, caused significant increases in plasma motilin levels at 40 to 90 min and somatostatin levels at 20 to 90 min, compared with a placebo treated group. Transient elevations of gastrin levels in the placebo group were inhibited by administration of Ninjin-to, but the medicine did not alter the levels of VIP. In conclusion, these results suggest that pharmacological effects of Ninjin-to on gastrointestinal functions closely relate to changes of motilin, gastrin, and somatostatin-immunoreactive substance levels in human plasma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:10:59