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Titolo:
Extract from Serenoa repens suppresses the invasion activity of human urological cancer cells by inhibiting urokinase-type plasminogen activator
Autore:
Ishii, K; Usui, S; Sugimura, Y; Yamamoto, H; Yoshikawa, K; Hirano, K;
Indirizzi:
Gifu Pharmaceut Univ, Lab Pharmaceut, Gifu 5028585, Japan Gifu Pharmaceut Univ Gifu Japan 5028585 Pharmaceut, Gifu 5028585, Japan Aichi Canc Ctr, Res Inst, Dept Urol, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan Toyama Prefectural Cent Hosp, Toyama 9308550, Japan Toyama Prefectural Cent Hosp Toyama Japan 9308550 Toyama 9308550, Japan Aichi Med Univ, Dept Pathol 2, Nagakute, Aichi 48011995, Japan Aichi Med Univ Nagakute Aichi Japan 48011995 akute, Aichi 48011995, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 2, volume: 24, anno: 2001,
pagine: 188 - 190
SICI:
0918-6158(200102)24:2<188:EFSRST>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACIDS; RECEPTOR; BINDING;
Keywords:
Serenoa repens; urokinase-type plasminogen activator; tumor cell invasion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hirano, K Gifu Pharmaceut Univ, Lab Pharmaceut, 5-6-1 Mitahora Higashi, Gifu 5028585, Japan Gifu Pharmaceut Univ 5-6-1 Mitahora Higashi Gifu Japan 5028585
Citazione:
K. Ishii et al., "Extract from Serenoa repens suppresses the invasion activity of human urological cancer cells by inhibiting urokinase-type plasminogen activator", BIOL PHAR B, 24(2), 2001, pp. 188-190

Abstract

We used three human urological cancer cell lines, PC-3, LNCaP and SKRC-1, to investigate the effects of the extract from Serenoa repens (Palmae) on tumor cell invasion. The invasion activity of these cell lines was determined in vitro using a Transwell cell-culture chamber. The invasion activity ofPC-3 cells into Matrigel was effectively suppressed by the extract at the concentration range of 1-10 mug/ml, while that of LNCaP and SKRC-1 cells was unaffected by the extract. The extract did not affect the viability, adhesion ability, or motility of the cell lines. uPA is more strongly expressedon the membrane fraction of PC-3 cells than that of LNCaP or SKRC-1 cells. The purified uPA activity is inhibited by the extract from S. repens in a dose-dependent manner, suggesting that the suppression of PC-3 cell invasion by the extract is based on an inhibition of the uPA activity which is necessary for tumor cell invasion. These data suggest that the extract from S.repens specifically inhibits the uPA activity and may therefore be useful for the therapeutic treatment of prostate cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 08:14:37