Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats
Autore:
Tsuji, S; Kawano, S; Tsujii, M; Kawai, N; Gunawan, ES; Sun, WH; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 nal Med & Therapeut, Osaka 5650871, Japan
Titolo Testata:
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
fascicolo: 1, volume: 51, anno: 2001,
pagine: 46 - 50
SICI:
0004-4172(2001)51:1<46:EOO(AI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTAMINE H-2-RECEPTOR ANTAGONIST; NITRIC-OXIDE; INJURY; PROSTAGLANDINS; CYTOPROTECTION; SUCRALFATE; CIMETIDINE; RANITIDINE; NECROSIS; STASIS;
Keywords:
anti-ulcer agent; CAS 140695-21-2; gastric hemodynamics; gastric mucosal blood flow; osutidine, enatiomers; T-593;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuji, S Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, 2-2 Yamadaoka, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Osaka Japan 5650871 saka 5650871, Japan
Citazione:
S. Tsuji et al., "Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats", ARZNEI-FOR, 51(1), 2001, pp. 46-50

Abstract

T-593 (osutidine, CAS 140695-21-2) is a new anti-ulcer agent that consistsof two enantiomers, (+)-(R)-T-593 and (-)-(S)-T-593. The present study wasdesigned to investigate the effects of T-593, (+)-(R)-T-593 and (-)-(S)-T-593 on ethanol-induced gastric damage in rats. Rats were given intraperitoneal administration of vehicle, racemic T-593, (+)-(R)-T-593 or (-)-(S)-T-593. 30 min later, the rats intragastrically received a 1-ml solution of 40 %ethanol, and 30 min thereafter, they were sacrificed for assessment of gastric damage. Gastric hemodynamics were assessed by reflectance spectrophotometry and laser Doppler flowmetry during the experiment. Gastric damage wassignificantly suppressed by racemic T-593 In a dose-dependent manner. While 60 mg/kg of (+)-(R)-T-593 and (-)-(S)-T-593 also suppressed ethanol-induced gastric injury the same dose of racemic T-593 exerted the most potent anti-ulcerative activity. Both (+)-(6)-T-593 and racemic T-593 increased gastric mucosal blood flow and abolished gastric mucosal blood flow stasis induced by 40 % ethanol. Although (-)-(S)-T-593, which antagonizes histamine H-2-receptors, exerts an antiulcerative effect, (+)-(6)-T-593 also protects the gastric mucosa from ethanol-induced Injury, possibly by influencing gastric mucosal hemodynamics. Thus racemic T-593 may protect the gastric mucosaby antagonizing H-2-receptors and by enhancing gastric circulation in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:51:03