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Titolo:
Glucose tolerance and cardiovascular mortality - Comparison of fasting and2-hour diagnostic criteria
Autore:
Borch-Johnsen, K; Neil, A; Balkau, B; Larsen, S; Nissinen, A; Pekkanen, J; Tuomilehto, J; Jousilahti, P; Lindstrom, J; Pyorala, M; Pyorala, K; Eschwege, E; Gallus, G; Garancini, MP; Bouter, LM; Dekker, JM; Heine, RJ; Nijpels, HG; Stehouwer, CDA; Feskens, EJM; Kromhout, D; Peltonen, M; Pajak, A; Eriksson, J; Qiao, Q;
Titolo Testata:
ARCHIVES OF INTERNAL MEDICINE
fascicolo: 3, volume: 161, anno: 2001,
pagine: 397 - 405
SICI:
0003-9926(20010212)161:3<397:GTACM->2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; BLOOD-GLUCOSE; RISK FACTOR; FOLLOW-UP; ASYMPTOMATIC HYPERGLYCEMIA; DIABETES-MELLITUS; HELSINKI POLICEMEN; NONDIABETIC MEN; ALL-CAUSE; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Qiao, Q Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet & Genet Epidemiol Unit, Mannerheimintie 166, FIN-00300 Helsinki, Finland Natl Publ Hlth Inst Mannerheimintie 166 Helsinki Finland FIN-00300
Citazione:
K. Borch-Johnsen et al., "Glucose tolerance and cardiovascular mortality - Comparison of fasting and2-hour diagnostic criteria", ARCH IN MED, 161(3), 2001, pp. 397-405

Abstract

Background: New diagnostic criteria for diabetes based on fasting blood glucose (FBG) level were approved by the American Diabetes Association. The impact of using FBG only has not been evaluated thoroughly. The fasting and the 2-hour glucose (2h-BG) criteria were compared with regard to the prediction of mortality. Methods: Existing baseline data on glucose level at fasting and 2 hours after a 75-g oral glucose tolerance test from 10 prospective European cohort studies including 15388 men and 7126 women aged 30 to 89 years, with a median follow-up of 8.8 years, were analyzed. Hazards ratios for death from allcauses, cardiovascular disease, coronary heart disease, and stroke were estimated. Results: Multivariate Cox regression analyses showed that the inclusion ofFBG did not add significant information on the prediction of 2h-BG alone (P>.10 for various causes), whereas the addition of 2h-BG to FBG criteria significantly improved the prediction (P<.001 for all causes and P<.005 for cardiovascular disease). In a model including FBG and 2h-BG simultaneously, hazards ratios (95% confidence intervals) in subjects with diabetes on 2h-BG were 1.73 (1.45-2.06) for all causes, 1.40 (1.02-1.92) for cardiovasculardisease, 1.56 (1.03 2.36) for coronary heart disease, and 1.29 (0.66-2.54)for stroke mortality, compared with the normal 2h-BG group. Compared with the normal FBG group, the corresponding hazards ratios in subjects with diabetes on FBG were 1.21(1.01-1.44), 1.20 (0.88-1.64), 1.09 (0.71-1.67), and 1.64 (0.88-3.07), respectively. The largest number of excess deaths was observed in subjects who had impaired glucose tolerance but normal FBG levels. Conclusions: The 2h-BG is a better predictor of deaths from all causes andcardiovascular disease than is FBG.

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Documento generato il 03/04/20 alle ore 20:13:08