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Titolo:
Using the prevalence of an elevated serum alanine aminotransferase level for identifying communities with a high prevalence of hepatitis C virus infection
Autore:
Wang, CS; Wang, ST; Chou, P;
Indirizzi:
Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Inst Publ Hlth, Taipei 112, Taiwan Natl Yang Ming Univ, Community Med Res Ctr, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 ty Med Res Ctr, Taipei 112, Taiwan Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 Publ Hlth, Tainan 70101, Taiwan A Lein Community Hlth Ctr, Kaohsiung, Taiwan A Lein Community Hlth Ctr Kaohsiung Taiwan Hlth Ctr, Kaohsiung, Taiwan
Titolo Testata:
ARCHIVES OF INTERNAL MEDICINE
fascicolo: 3, volume: 161, anno: 2001,
pagine: 392 - 394
SICI:
0003-9926(20010212)161:3<392:UTPOAE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCREENING ASYMPTOMATIC PEOPLE; BLOOD-DONORS; RISK-FACTORS; CONTROVERSIES; MANAGEMENT; TAIWAN; AREA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Chou, P Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 l Hlth, Taipei 112, Taiwan
Citazione:
C.S. Wang et al., "Using the prevalence of an elevated serum alanine aminotransferase level for identifying communities with a high prevalence of hepatitis C virus infection", ARCH IN MED, 161(3), 2001, pp. 392-394

Abstract

Background: Antibody to hepatitis C virus (anti-HCV) is a widely accepted method for the diagnosis of HCV infection. However, it is too expensive to use in large-scale health surveys. Objective: To investigate the use of the serum alanine aminotransferase (ALT) level to predict the prevalence of HCV infection. Patients and Methods: A sample of 6095 residents aged 35 years old or older in a small township of southern Taiwan, Republic of China, were examined in a community health survey. These persons were walk-ins to the government-sponsored stations after an intensive health promotion for this surrey. Blood samples were obtained and analyzed for serum ALT levels. The presence of hepatitis B surface antigen and anti-HCV were determined by enzyme immunoassay methods. Results: The overall prevalences of hepatitis B surface antigens(+), anti-HCV(+), and elevated ALT levels were 11.8%, 15.0%, and 7.5%, respectively. Among the 13 villages in this community, the prevalence of hepatitis B surface antigen(+) ranged from 6.8% to 17.3%, anti-HCV(+) ranged from 7.2% to 37.6%, and an elevated ALT level ranged from 5.8% to 16.5%. A strong positive correlation was found between the prevalence of an elevated ALT level andanti-HCV(+) (r = 0.91, Spearman rank correlation; P<.001). However, nearly0 correlation (r = -0.05, P = .87) was obtained between the prevalence of an elevated serum ALT level and hepatitis B surface antigen(+). Conclusion: The prevalence of an elevated serum ALT level in a community is a strong indicator of its prevalence of anti-HCV CV(+), even in areas where there is a similar prevalence of hepatitis B virus infection. This result is useful for economically identifying hyperendemic communities with HCV infection.

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Documento generato il 19/07/18 alle ore 13:30:07