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Titolo:
METHACHOLINE CHALLENGE TESTING - SAFETY OF LOW STARTING FEV1
Autore:
MARTIN RJ; WANGER JS; IRVIN CG; BARTELSON BB; CHERNIACK RM; DRAZEN JM; ISRAEL E; MARTIN RJ; SZEFLER SJ; CHINCHILLI VM; MAUGER EA; LEMANSKE RF; SORKNESS C; FORD JG; MCLEAN D; NOCHMAN S; FISH JE; PETERS SP; BOUSHEY HA; LAZARUS SC; FAHY J; CHERNIACK RR; HURD SS;
Indirizzi:
NATL JEWISH MED & RES CTR,ROOM J-116,1400 JACKSON ST DENVER CO 80206 NATL JEWISH CTR IMMUNOL & RESP MED DENVER CO 80206
Titolo Testata:
Chest
fascicolo: 1, volume: 112, anno: 1997,
pagine: 53 - 56
SICI:
0012-3692(1997)112:1<53:MCT-SO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL HYPERREACTIVITY; RESPONSIVENESS; ASTHMA;
Keywords:
ASTHMA; METHACHOLINE CHALLENGE; SAFETY; STARTING FEV1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Martin et al., "METHACHOLINE CHALLENGE TESTING - SAFETY OF LOW STARTING FEV1", Chest, 112(1), 1997, pp. 53-56

Abstract

Study objective: The lower limit for the baseline value to initiate methacholine bronchial hyperresponsiveness testing has not been well established. Recommendations have varied from > 1 L to above 80% of predicted. The objective was to determine if an FEV1 < 60% predicted was acceptable. Design: Retrospective analysis of challenges in 88 patientswith a baseline FEV1 of <60% predicted (mean=45.8%; range, 22 to 59%. Setting: Academic institutions. Results: There were only four individuals whose FEV1 did not return to >90% of baseline following one poststudy beta(2)-agonist treatment. All four responded to a second treatment. There were no adverse sequelae following challenge in any individual. Neither age (up to 79 years) nor gender influenced outcome. Conclusions: In chronic moderate to severe asthma, it appears that bronchialhyperresponsiveness testing can be safely performed even in those patients with a low baseline FEV1.

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Documento generato il 15/07/20 alle ore 08:48:57