Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Ethanol-induced apoptotic neurodegeneration in the developing brain
Autore:
Olney, JW; Ishimaru, MJ; Bittigau, P; Ikonomidou, C;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Tokyo Med & Dent Univ, Med Res Inst, Chiyoda Ku, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan ed Res Inst, Chiyoda Ku, Tokyo, Japan Humboldt Univ, Dept Pediat Neurol, Charite, D-13353 Berlin, Germany Humboldt Univ Berlin Germany D-13353 l, Charite, D-13353 Berlin, Germany
Titolo Testata:
APOPTOSIS
fascicolo: 6, volume: 5, anno: 2000,
pagine: 515 - 521
SICI:
1360-8185(200012)5:6<515:EANITD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL-ALCOHOL-SYNDROME; CENTRAL-NERVOUS-SYSTEM; DEVELOPING RAT-BRAIN; NMDA ANTAGONISTS; CAUTIONARY NOTE; HEAD TRAUMA; CELL-DEATH; NEUROTOXICITY; DEGENERATION; DAMAGE;
Keywords:
anesthetics; apoptosis; barbiturates; benzodiazepines; ethanol; GABA(A) receptors; ketamine; NMDA receptors; phencyclidine; synaptogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Olney, JW Washington Univ, Sch Med, Dept Psychiat, 4940 Childrens Pl, St Louis, MO 63110 USA Washington Univ 4940 Childrens Pl St Louis MO USA 63110 3110 USA
Citazione:
J.W. Olney et al., "Ethanol-induced apoptotic neurodegeneration in the developing brain", APOPTOSIS, 5(6), 2000, pp. 515-521

Abstract

It has been known for three decades that ethanol, the most widely abused drug in the world, has deleterious effects on the developing human brain, but progress has been slow in developing animal models for studying this problem, and the underlying mechanisms have remained elusive. Recently, we haveshown that during the synaptogenesis period, also known as the brain growth spurt period, ethanol has the potential to trigger massive neuronal suicide in the in vivo mammalian brain. The brain growth spurt period in humans spans the last trimester of pregnancy and first several years after birth. The NMDA antagonist and GABAmimetic properties of ethanol may be responsible for its apoptogenic action, in that other drugs with either NMDA antagonist or GABAmimetic actions also trigger apoptotic neurodegeneration in the developing brain. Our findings provide a likely explanation for the reduced brain mass and neurobehavioral disturbances associated with the human fetalalcohol syndrome. Furthermore, since NMDA antagonist and GABAmimetic drugsare sometimes abused by pregnant women and also are used as anticonvulsants, sedatives or anesthetics in pediatric medicine, our findings raise several complex drug safety issues. In addition, the observation that ethanol and several other drugs trigger massive neuronal apoptosis in the developing brain provides an unprecedented opportunity to study both neuropathologicalaspects and molecular mechanisms of apoptotic neurodegeneration in the in vivo mammalian brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:42:35