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Titolo:
A prospective study of blood pressure and risk of cataract in men
Autore:
Schaumberg, DA; Glynn, RJ; Christen, WG; Ajani, UA; Sturmer, T; Hennekens, CH;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 d, Div Prevent Med, Boston, MA 02215 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Dept Biostat, Boston, MA 02115 USA Univ Ulm, Dept Epidemiol, Ulm, Germany Univ Ulm Ulm GermanyUniv Ulm, Dept Epidemiol, Ulm, Germany Univ Miami, Sch Med, Dept Med, Miami, FL USA Univ Miami Miami FL USAUniv Miami, Sch Med, Dept Med, Miami, FL USA Univ Miami, Sch Med, Dept Epidemiol & Publ Hlth, Miami, FL USA Univ MiamiMiami FL USA h Med, Dept Epidemiol & Publ Hlth, Miami, FL USA
Titolo Testata:
ANNALS OF EPIDEMIOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 104 - 110
SICI:
1047-2797(200102)11:2<104:APSOBP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTERIOR SUBCAPSULAR CATARACTS; BEAVER DAM EYE; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; RANDOMIZED TRIAL; LENS OPACITIES; HYPERTENSION; PHYSICIANS; ASPIRIN; ASSOCIATION;
Keywords:
blood pressure; cataract; epidemiology; hypertension; Physicians' Health Study; risk factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Schaumberg, DA Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, 900 Commonwealth Ave E, Boston, MA 02215 USA Harvard Univ 900 Commonwealth Ave E Boston MA USA 02215 USA
Citazione:
D.A. Schaumberg et al., "A prospective study of blood pressure and risk of cataract in men", ANN EPIDEMI, 11(2), 2001, pp. 104-110

Abstract

PURPOSE: Cataract is the leading cause of blindness worldwide. Blood pressure has been identified as a risk factor in some, but not all, previous studies. We aimed to test prospectively the hypothesis that high blood pressure increases risk of age-related cataract. METHODS: Participants in the Physicians' Health Study of 22,071 men aged 40 tcr 84 years in 1982 completed annual questionnaires that provided medical history including self-reported blood pressure, treatment for hypertension, and cataract. Over 12 years, 1392 cataracts: were confirmed by medical record review among 17,762 physicians with complete data and no reported cataract at baseline. We used proportional hazards regression models to examine relations of systolic blood pressure (SBP), diastolic blood pressure (DBP), hypertension, as well as antihypertensive medications: with cataract, after control for potential confounding factors. RESULTS: In models adjusting for age and randomized treatment assignment, there was a significant relationship of SEP (P = 0.01), but not DBP (p = 0.30), hypertension (p = 0.15), or antihypertensive medications teach p greater than or equal to 0.23) with incident cataract. Estimates were attenuatedafter adjusting for multiple potential confounders, although the relationship of SEP with incident cataract remained significant. The multivariate adjusted rate ratio (95% confidence interval) of cataract for SBP greater than or equal to 150 versus < 120 mmHg was 1.31 (1.04-1.66), P for trend = 0.04. For DBP <greater than or equal to> 90 versus < 70 mmHg, the estimate was1.11 (0.84-1.45), P fur trend = 0.33. CONCLUSIONS: Overall, these data suggest that the relationship of blood pressure with cataract is not strong, and is subject to confounding by other risk factors. The modest magnitude of the association with SEP and lack of significant relationships with DBP and hypertension may suggest a non-causal relationship of blood pressure with cataract. Ann Epidemiol 2001;11:104-110. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:49:57