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Titolo:
Maternal expression of functional lipoprotein lipase and effects on body fat mass and body condition scores of mature cats with lipoprotein lipase deficiency
Autore:
Backus, RC; Ginzinger, DG; Excoffon, KJDA; Clee, SM; Hayden, MR; Eckel, RH; Hickman, MA; Rogers, QR;
Indirizzi:
Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Dept Mol Biosci, Davis, CA 95616 USA Univ Calif Davis, Sch Vet Med, Dept Anat Physiol & Cell Biol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 siol & Cell Biol, Davis, CA 95616 USA Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada Univ Colorado, Hlth Sci Ctr, Dept Med, Div Endocrinol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 d, Div Endocrinol, Denver, CO 80262 USA
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 2, volume: 62, anno: 2001,
pagine: 264 - 269
SICI:
0002-9645(200102)62:2<264:MEOFLL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOLOGICAL-FLUIDS; ENZYME-ACTIVITY; ADIPOSE-TISSUE; DOMESTIC CATS; MICE; HETEROZYGOTES; METABOLISM; WATER; ACID; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Backus, RC Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616USA Univ Calif Davis Davis CA USA 95616 iosci, Davis, CA 95616 USA
Citazione:
R.C. Backus et al., "Maternal expression of functional lipoprotein lipase and effects on body fat mass and body condition scores of mature cats with lipoprotein lipase deficiency", AM J VET RE, 62(2), 2001, pp. 264-269

Abstract

Objective-To assess effects of deficiency of lipoprotein lipase (LPL) on body condition scores and lean and fat body masses of adult cats. Animals-12 cats without LPL mutations and 23 cats that were heterozygous or homozygous carriers of the Gly412Arg LPL mutation. Procedure-Lean and fat body masses were estimated by use of body conditionscores and change in enrichment of serum after IV administration of deuterium oxide. Mass spectroscopy and infrared absorbance methods were used to determine deuterium enrichment. Results-Fat body mass (mean +/- SD; 0.2 +/- 0.1 kg) and percentage body fat (6.2 +/- 1.4%) of homozygotes were significantly less than those of clinically normal cats and heterozygotes (0.7 +/- 0.1 kg, 18.2 +/- 1.6% and 0.5 /- 0.1 kg, 15.6 +/- 1.7%, respectively). Homozygous offspring of homozygous dams had significantly less fat body mass (0.1 +/- 0.1 kg) and percentagebody fat (2.1 +/- 1.0%) than homozygous off spring of heterozygous dams (0.3 +/- 0.1 kg and 9.2 +/- 1.7%, respectively). Lean body mass did not differ significantly among groups. For all groups, percent age body fat was significantly correlated with body condition score (r = 0.65), and body condition scores supported findings for fat body mass. Conclusions and Clinical Relevance-Deficiency of LPL activity in cats diminishes stores of body fat. This is consistent with a low rate of de novo synthesis of fat. The effect of dam on body masses in mature LIL-deficient cats indicates nutrient programming of adipose formation during gestation or lactation.

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Documento generato il 01/04/20 alle ore 20:52:09