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Titolo:
Sertraline treatment of generalized social phobia: A 20-week, double-blind, placebo-controlled study
Autore:
Van Ameringen, MA; Lane, RM; Walker, JR; Bowen, RC; Chokka, PR; Goldner, EM; Johnston, DG; Lavallee, YJ; Nandy, S; Pecknold, JC; Hadrava, V; Swinson, RP;
Indirizzi:
McMaster Univ, Med Ctr, Anxiety Disorders Clin, Hamilton Hlth Sci Corp, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 rp, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8S 4L8, Canada McMaster Univ Hamilton ON Canada L8S 4L8 ci, Hamilton, ON L8S 4L8, Canada Pfizer Inc, Sertraline Social Phobia Study Grp, New York, NY USA Pfizer Inc New York NY USA ine Social Phobia Study Grp, New York, NY USA Pfizer Inc, Pfizer Pharmaceut Grp, New York, NY USA Pfizer Inc New York NY USA Inc, Pfizer Pharmaceut Grp, New York, NY USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 2, volume: 158, anno: 2001,
pagine: 275 - 281
SICI:
0002-953X(200102)158:2<275:STOGSP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANXIETY DISORDER; CONTROLLED TRIAL; SCALE; MOCLOBEMIDE; PHENELZINE; PHARMACOTHERAPY; FLUVOXAMINE; IMPAIRMENT; ATENOLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Van Ameringen, MA McMaster Univ, Med Ctr, Anxiety Disorders Clin, HamiltonHlth Sci Corp, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada McMaster Univ 1200 Main St W Hamilton ON Canada L8N 3Z5
Citazione:
M.A. Van Ameringen et al., "Sertraline treatment of generalized social phobia: A 20-week, double-blind, placebo-controlled study", AM J PSYCHI, 158(2), 2001, pp. 275-281

Abstract

Objective: The authors evaluated the efficacy, safety, and tolerability ofsertraline, a selective serotonin reuptake inhibitor, in the treatment of generalized social phobia. Method: Adult outpatients with generalized social phobia (N=204) from 10 Canadian centers were randomly assigned to receive sertraline or placebo in a 2:2 ratio for a 20-week double-blind study following a I-week, single-blind, placebo run-in. The initial dose of sertraline was 50 mg/day with increases of 50 mg/day every 3 weeks permitted after the fourth week of treatment (dosing was flexible up to a maximum of 200 mg/day). Primary efficacy assessments were the percentage of patients rated much or very much improved on the Clinical Global Impression (CGI) improvement item and the mean changes from baseline to study endpoint in total score on the social phobia subscale of the Marks Fear Questionnaire and total score on the Brief Social Phobia Scale. Results: In intent-to-treat endpoint analyses of 203 of the patients, significantly more of the 134 patients given sertraline (N=71 [53%]) than of the 69 patients receiving placebo (N=20 [29%]) were considered responders according to their CGI improvement scores at the end of treatment. The mean reductions in the social phobia subscale of the Marks Fear Questionnaire and in the total score on the Brief Social Phobia Scale were 32.6% and 34.3% inthe sertraline group and 10.8% and 18.6% in the placebo group, respectively. Analysis of covariance showed superiority of sertraline over placebo on all primary and secondary efficacy measures. Sertraline was well tolerated:103 (76%) of the 135 sertraline-treated patients and 54 (78%) of the 69 placebo-treated patients completed the study. Conclusions: Sertraline is an effective treatment for patients with generalized social phobia.

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Documento generato il 29/03/20 alle ore 15:24:31