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Titolo:
Three-dimensional mapping of gyral shape and cortical surface asymmetries in schizophrenia: Gender effects
Autore:
Narr, KL; Thompson, PM; Sharma, T; Moussai, J; Zoumalan, C; Rayman, J; Toga, AW;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Div Brain Mapping, Dept Neurol,Lab Neuro Imaging, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Inst Psychiat, Sect Cognit Psychopharmacol, London, England Inst PsychiatLondon England ct Cognit Psychopharmacol, London, England
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 2, volume: 158, anno: 2001,
pagine: 244 - 255
SICI:
0002-953X(200102)158:2<244:TMOGSA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLANUM TEMPORALE ASYMMETRY; MAGNETIC-RESONANCE IMAGES; HUMAN-BRAIN; CEREBRAL ASYMMETRY; SYLVIAN FISSURE; EPISODE SCHIZOPHRENIA; PROBABILISTIC ATLAS; CORPUS-CALLOSUM; MAUDSLEY FAMILY; SEX-DIFFERENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Toga, AW Univ Calif Los Angeles, Sch Med, Div Brain Mapping, Dept Neurol,Lab Neuro Imaging, 710 Westwood Plaza, Los Angeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
K.L. Narr et al., "Three-dimensional mapping of gyral shape and cortical surface asymmetries in schizophrenia: Gender effects", AM J PSYCHI, 158(2), 2001, pp. 244-255

Abstract

Objective: People with schizophrenia exhibit abnormalities in brain structure, often in the left hemisphere. Disturbed structural lateralization is controversial, however, and effects appear mediated by gender. The authors mapped differences between schizophrenic and normal subjects in gyral asymmetries, complexity, and variability across the entire cortex. Method: Asymmetry and shape profiles for 25 schizophrenic patients (15 men) and 28 demographically similar normal subjects (15 men) were obtained for38 gyral regions, including the sylvian fissure and temporal and postcentral gyri, by using magnetic resonance data and a novel surface-based mesh-modeling approach. Cortical complexity was examined for sex and diagnosis effects in lobar regions. Intragroup variability was quantified and visualizedto assess regional group abnormalities at the cortical surface. Results: The patients showed greater variability in frontal areas than thecomparison subjects. They also had significant deviations in gyral complexity asymmetry in the superior frontal cortex. In temporoparietal regions, significant gyral asymmetries were present in both groups. Sex differences were apparent in superior temporal gyral measures, and cortical complexity in inferior frontal regions was significantly greater in men. Conclusions: Cortical variability and complexity show regional abnormalities in the frontal cortex potentially specific to schizophrenia. The resultsindicate highly significant temporoparietal gyral asymmetries in both diagnostic groups, contrary to reports of less lateralization in schizophrenia. Substantially larger study groups are necessary to isolate smaller deviations in surface asymmetries, if present in schizophrenia, suggesting their diagnostic value is minimal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:49:44