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Titolo:
Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice
Autore:
Glaab, T; Daser, A; Braun, A; Neuhaus-Steinmetz, U; Fabel, H; Alarie, Y; Renz, H;
Indirizzi:
Hannover Med Sch, Dept Resp Med, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 Med, D-30625 Hannover, Germany Humboldt Univ, Charite Campus Virchow Clin, Inst Lab Med & Pathobiochem, D-13353 Berlin, Germany Humboldt Univ Berlin Germany D-13353 thobiochem, D-13353 Berlin, Germany Univ Marburg, Inst Clin Chem & Mol Diagnost, D-35043 Marburg, Germany UnivMarburg Marburg Germany D-35043 Diagnost, D-35043 Marburg, Germany Univ Pittsburgh, Grad Sch Publ Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA 15238 USA Univ Pittsburgh Pittsburgh PA USA 15238 at Hlth, Pittsburgh, PA 15238 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 3, volume: 280, anno: 2001,
pagine: L565 - L573
SICI:
1040-0605(200103)280:3<L565:TMFAAM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IGE PRODUCTION; MOUSE MODEL; RESPONSIVENESS; HYPERREACTIVITY; OBSTRUCTION; ASTHMA; IL-5;
Keywords:
body plethysmography; allergy; lung function method;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Glaab, T Hannover Med Sch, Dept Resp Med, Carl Neuberg Str 1, D-30625 Hannover, Germany Hannover Med Sch Carl Neuberg Str 1 Hannover Germany D-30625any
Citazione:
T. Glaab et al., "Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice", AM J P-LUNG, 280(3), 2001, pp. L565-L573

Abstract

A method for the noninvasive measurement of airway responsiveness was validated in allergic BALB/c mice. With head-out body plethysmography and the decrease in tidal midexpiratory flow (EF50) as an indicator of airway obstruction, responses to inhaled methacholine (MCh) and the allergen ovalbumin were measured in conscious mice. Allergen-sensitized and -challenged mice developed airway hyperresponsiveness as measured by EF50 to aerosolized MCh compared with that in control animals. This response was associated with increased allergen-specific IgE and IgG1 production, increased levels of interleukin-4 and interleukin-5 in bronchoalveolar lavage fluid and eosinophiliclung inflammation. Ovalbumin aerosol challenge elicited no acute bronchoconstriction but resulted in a significant decline in EF50 baseline values 24h after challenge in allergic mice. The decline in EF50 to MCh challenge correlated closely with simultaneous decreases in pulmonary conductance and dynamic compliance. The decrease in EF50 was partly inhibited by pretreatment with the inhaled beta (2)-agonist salbutamol. We conclude that measurement of EF50 to inhaled bronchoconstrictors by head-out body plethysmography is a valid measure of airway hyperresponsiveness in mice.

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Documento generato il 29/09/20 alle ore 10:14:47