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Titolo:
Totally necrotic choroidal and ciliary body melanomas: Associations with prognosis, episcleritis, and scleritis
Autore:
Moshari, A; Cheeseman, EW; McLean, IW;
Indirizzi:
Armed Forces Inst Pathol, Dept Ophthalm Pathol, Washington, DC 20306 USA Armed Forces Inst Pathol Washington DC USA 20306 Washington, DC 20306 USA
Titolo Testata:
AMERICAN JOURNAL OF OPHTHALMOLOGY
fascicolo: 2, volume: 131, anno: 2001,
pagine: 232 - 236
SICI:
0002-9394(200102)131:2<232:TNCACB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
UVEAL MALIGNANT-MELANOMA; ENUCLEATION; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Moshari, A Armed Forces Inst Pathol, Dept Ophthalm Pathol, Washington, DC 20306 USA Armed Forces Inst Pathol Washington DC USA 20306 DC 20306 USA
Citazione:
A. Moshari et al., "Totally necrotic choroidal and ciliary body melanomas: Associations with prognosis, episcleritis, and scleritis", AM J OPHTH, 131(2), 2001, pp. 232-236

Abstract

PURPOSE: To report associations between prognosis, total tumor necrosis, scleritis, and episcleritis in choroidal and ciliary body melanomas. METHODS: In this retrospective observational histopathologic study, 157 totally necrotic melanomas and 177 melanomas that were not totally necrotic of choroidal and ciliary body were retrieved from the Registry of OphthalmicPathology. The eyes were examined for the histologic evidence of inflammatory cells within the sclera and episcleral tissues. Contingency table, Kaplan-Meier, and Cox proportional hazard regression analyses were performed. In the survival analyses, only deaths with metastatic melanoma were considered as events in the statistical analysis. RESULTS: Among the totally necrotic melanomas, 118 of 157 (75.1%) had bothepiscleritis and scleritis; two of 157 (1.3%) had scleritis only; 29 of 157 (18.5%) had episcleritis only; and eight of 157 (5.1%) had neither episcleritis nor scleritis. Among the non-necrotic melanomas, 23 of 177 (12.9%) had both episcleritis and scleritis; eight of 177 (4.5%) had scleritis only;71 of 177 (40.1%) had episcleritis only; and 75 of 177 (42.3%) had neitherepiscleritis nor scleritis. Cox regression indicated that total necrosis and scleritis were prognostically significant (P<.05) when analyzed univariately but not significant when analyzed multivariately with tumor size. CONCLUSIONS: Scleritis and episcleritis were statistically significantly associated with total tumor necrosis. There was a higher incidence of episcleritis than scleritis in both the necrotic and non-necrotic tumor types. Associations with patient outcome were identified for necrosis and scleritis. However, these associations were statistically insignificant when the prognostic effect of tumor size was also considered in a multivariate model. (Am J Ophthalmol 2001;131:232-236. Published by Elsevier Science Inc).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:25:48