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The age-related eye disease study (AREDS) system for classifying cataractsfrom photographs: AREDS report No. 4
Kassoff, A; Kassoff, J; Mehu, M; Buehler, J; Eglow, M; Kaufman, F; Kieval, S; Margherio, RR; Cox, MS; Garretson, B; Hassan, T; Ruby, A; Trese, MT; Werner, JC; Williams, GA; Regan, V; Manatrey, P; Cumming, K; Lewis, B; Zajechowski, M; Falk, R; Streasick, P; Szydlowski, L; McIver, F; Bridges, C; Stanley, C; Klein, ML; Robertson, JE; Wilson, DJ; Beardsley, C; Smith, G; Howard, S; Dreyer, RF; Ma, C; Chenoweth, RG; Zilis, JD; Crider, H; Parker, S; Sherman, K; Martin, D; Aaberg, TM; Aaberg, TM; Sternberg, P; Curtis, L; Gilman, J; Myles, B; Armiger, D; Capone, A; Saperstein, D; Stribling, B; Swords, R; Orth, DH; Flood, TP; Civantos, J; deBustros, S; Packo, KH; Merrill, PT; MacLeod, C; Morrison, C; Bryant, DA; Doherty, D; Sandoval, S; Seddon, JM; Pinnolis, MK; Jones-Devonish, DA; Evans, C; Davis, N; Callahan, C; Walsh, D; Dubois, J; Burton, I; Rosenberg, NJ; Patel, P; Crouse, VD; Snow, KK; Chew, EY; Ferris, FL; Csaky, K; Dabas, KH; Goodman, L; Kim, YJ; Mercer, R; Palmer, MC; Ciatto, PF; Kuehl, E; Kivitz, I; Koutsandreas, D; Nashwinter, R; Haughey, M; Babilonia-Ayukawa, G; La-Reau, A; McCarthy, SA; Ayres, LM; Lopez, P; Randall, A; Friberg, TR; Eller, A; Gorin, MB; Alexander, J; Mack, B; Paine, MK; Corbin, PS; Curtin, DY; Ostroska, PP; Warnicki, J; Fijewski, E; Bressler, SB; Bressler, NM; Cassel, G; Finkelstein, D; Goldberg, M; Haller, JA; Ratner, L; Schachat, AP; Sherman, SH; Sunness, JS; Schnenning, S; Sackett, C; Belt, J; Cain, D; Emmert, D; Herring, M; George, T; Wheeler, S; Elman, MJ; Ballinger, R; Betancourt, A; Glasser, D; Lammlein, J; Seff, R; Shuman, M; Starr, J; Carrigan, A; Mathews, T; Sotirakos, P; Cain, T; Ringrose, C; Chandra, SR; Davis, MD; Ip, M; Klein, R; Nork, TM; Stevens, T; Blodi, B; Gottlieb, J; Walker, W; Soderling, B; Schmitz, M; Perkins, T; Blatz, M; Harrison, B; Knutson, G; Neider, M; Peterson, J; Krolnik, D; Somers, G; Myers, FL; Davis, MD; Klein, BEK; Klein, R; Hubbard, L; Armstrong, J; Neider, M; Wabers, H; Kastorff, L; Lang, K; Badal, D; Geithman, PL; Miner, KD; Dohm, KL; Onofrey, JA; Esser, B; Hurtenbach, C; Fisher, MR; Robinson, NL; Baliker, J; Gai, C; Craanen, S; Webster, M; Elledge, J; Reed, S; Bent, W; Glander, KE; Osterby, KR; Reimers, J; Magli, YL; Brickbauer, J; Ansay, S; King, WN; Miller, D; Sowell, A; Gunter, E; Bowman, B; Lindblad, AS; Ederer, F; Milton, RC; Clemons, T; Gensler, G; Keller, A; Entler, G; Stine, E; Brunson, K; Berlin, SH; Pallas, S; Mengers, SA; Scholl, PR; Anand, R; Ferris, FL; Chew, EY; Sperduto, R; Kurinij, N;
Associated Retinal Consultants PC, Royal Oak, MI USA Associated Retinal Consultants PC Royal Oak MI USA PC, Royal Oak, MI USA Devers Eye Inst, Portland, OR USA Devers Eye Inst Portland OR USADevers Eye Inst, Portland, OR USA Emory Univ, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322Emory Univ, Atlanta, GA 30322 USA Ingalls Mem Hosp, Harvey, IL USA Ingalls Mem Hosp Harvey IL USAIngalls Mem Hosp, Harvey, IL USA Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA Massachusetts Eye & Ear Infirm Boston MA USA 02114 , Boston, MA 02114 USA NEI, Ctr Clin, Bethesda, MD USA NEI Bethesda MD USANEI, Ctr Clin, Bethesda, MD USA Univ Pittsburgh, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 tsburgh, Pittsburgh, PA 15260 USA Johns Hopkins Med Inst, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 st, Baltimore, MD 21205 USA Univ Wisconsin, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706Univ Wisconsin, Madison, WI 53706 USA Univ Wisconsin, Reading Ctr, Madison, WI 53706 USA Univ Wisconsin MadisonWI USA 53706 n, Reading Ctr, Madison, WI 53706 USA Ctr Dis Control & Prevent, Cent Lab, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA vent, Cent Lab, Atlanta, GA USA NEI, Project Off, Bethesda, MD USA NEI Bethesda MD USANEI, Project Off, Bethesda, MD USA NIH, Div Contracts & Grants, Bethesda, MD USA NIH Bethesda MD USANIH, Div Contracts & Grants, Bethesda, MD USA Bausch & Lomb Pharmaceut, Rochester, NY USA Bausch & Lomb Pharmaceut Rochester NY USA Pharmaceut, Rochester, NY USA EMMES Corp, AREDS Coordinating Ctr, Potomac, MD 20854 USA EMMES Corp Potomac MD USA 20854 S Coordinating Ctr, Potomac, MD 20854 USA
Titolo Testata:
fascicolo: 2, volume: 131, anno: 2001,
pagine: 167 - 175
Tipo documento:
Settore Disciplinare:
Clinical Medicine
Life Sciences
Indirizzi per estratti:
Indirizzo: Kassoff, A EMMES Corp, AREDS Coordinating Ctr, 11325 7 Locks Rd, Potomac, MD 20854 USA EMMES Corp 11325 7 Locks Rd Potomac MD USA 20854 , MD 20854 USA
A. Kassoff et al., "The age-related eye disease study (AREDS) system for classifying cataractsfrom photographs: AREDS report No. 4", AM J OPHTH, 131(2), 2001, pp. 167-175


PURPOSE: To describe the system for grading cataracts from photographs in the Age Related Eye Disease Study (AREDS). METHODS: The system for grading cataracts in AREDS uses photographs taken in a standardized fashion with specially modified cameras at 11 clinical centers, The photographs are evaluated by graders for quality and cataract severity at a central reading center, The area of lens involvement is used toassess the severity of cortical and posterior subcapsular opacities, Optical density of nuclear opacity is graded against a series of seven standard photographs. Contemporaneous variability in grading is evaluated periodically by having a second examiner regrade a subset of the photographs. Temporal variability is assessed by annually regrading a subset of photographs. RESULTS: Photographs of 925 eyes, most with no or early lens opacities, were regraded to assess intergrader reliability. For cortical opacities, there was an absolute difference of 10% or greater of area involved in 1.9% of the replicate gradings. For posterior subcapsular opacities an absolute difference of 5% of area involved was noted in 2.8% of the regraded photographs. For nuclear opacities, absolute differences of 1.5 or more steps were observed in 0.6% of eyes. There was little evidence of temporal drift in grading any of the three types of opacity during four annual regrades. CONCLUSIONS: We have demonstrated a high degree of reliability in grading the severity of lens opacities in a large study cohort with mostly early lens changes, the type of cohort most likely to be entered in clinical trialsinvolving cataract prevention. The Age-Related Eye Disease Study System for Classifying Cataracts From Photographs could be useful in studies where there is a need to standardize data collection over time and across different data collection sites. Limitations of the system include the cost of implementation and, currently, the limited amount of data on grading reproducibility for more advanced lens opacities. (Am J Ophthalmol 2001;131:167-175. (C) 2001 by Elsevier Science Inc. All rights reserved).

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