Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Potential role of endogenous antibiotic peptides in congenital defense mechanisms of rhinosinusitis
Autore:
Maune, S; Meyer, JE;
Indirizzi:
Univ Kiel, Klin Hals Nasen Ohrenheilkunde Kopf & Halschirurg, D-24105 Kiel, Germany Univ Kiel Kiel Germany D-24105 Kopf & Halschirurg, D-24105 Kiel, Germany
Titolo Testata:
ALLERGOLOGIE
fascicolo: 1, volume: 24, anno: 2001,
pagine: 23 - 32
SICI:
0344-5062(200101)24:1<23:PROEAP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
GER
Soggetto:
TRACHEAL EPITHELIAL-CELLS; AIRWAY SURFACE FLUID; ANTIMICROBIAL PEPTIDE; HUMAN BETA-DEFENSIN-2; CYSTIC-FIBROSIS; BETA-DEFENSIN; HOST-DEFENSE; HUMAN SKIN; EXPRESSION; ANTILEUKOPROTEASE;
Keywords:
antimicrobial peptides; innate immunity; endogenous antibiotics; rhinosinusitis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Maune, S Univ Kiel, Klin Hals Nasen Ohrenheilkunde Kopf & Halschirurg, Arnold Heller Str 14, D-24105 Kiel, Germany Univ Kiel Arnold Heller Str 14 Kiel Germany D-24105 iel, Germany
Citazione:
S. Maune e J.E. Meyer, "Potential role of endogenous antibiotic peptides in congenital defense mechanisms of rhinosinusitis", ALLERGOLOGI, 24(1), 2001, pp. 23-32

Abstract

Although surfaces of man are normally covered with microorganisms, infections of healthy skin or mucosa are rare. Reasons are apart from physical barriers production of gene encoded epithelial antimicrobial peptides (AP). Many novel AP have been discovered in human epithelia in the last decade, In situ hybridisation techniques showed an organspecific gene expression pattern of AP, which due to its antimicrobial spectrum and conditions of expression may also define the physiologic microflora. Some AP are constitutively expressed, others are induced by endogenous, proinflammatory cytokines or certain microbes through yet still unknown receptors. The majority of AP kills microbes by forming pores in the microbial membranes. The increasing sensitivity of AP towards cholesterol, an important part of mammalian cell membranes, and parallel the decreasing antimicrobial activity might explain, why AP usually don't attack human cells, Thus it seems to be difficult for microbes to acquire resistance against AP, because of the low molecular weight of AP, which makes it in vitro nearly impossible to digest AP. The firstclinical trials were very promising and after development of a large scalebiotechnical synthesis a number of novel AP could follow. Furthermore the discovery of the inducibility of many AP might also lead to the developmentof different substances that could stimulate endogenous AP production. This brief review summarises our current knowledge on AP within the human airway tract and discusses their potential role and relevance in the pathogenesis and therapy of rhinosinusitis. This includes the possibility of defective productions in patients with recurrent infections, the therapeutic use ofsynthetic AP and induction of their synthesis as an alternative strategy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:57:39