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Titolo:
Animal models of alcohol withdrawal
Autore:
Becker, HC;
Indirizzi:
Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 Sci, Charleston, SC 29425 USA Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA Dept Vet Affairs Med Ctr, Charleston, SC USA Dept Vet Affairs Med Ctr Charleston SC USA s Med Ctr, Charleston, SC USA
Titolo Testata:
ALCOHOL RESEARCH & HEALTH
fascicolo: 2, volume: 24, anno: 2000,
pagine: 105 -
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETHANOL WITHDRAWAL; ACOUSTIC STARTLE; SEIZURES; RATS; HYPEREXCITABILITY; DEPENDENCE; INDUCTION; DRINKING; HANGOVER; ANXIETY;
Keywords:
animal model; chronic AOD (alcohol or other drug) withdrawal syndrome; in vitro study; in vivo study; locomotion; AODR (AOD related) seizure; convulsion; drug discrimination; dysphoria; autonomic nervous system; symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, HC Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 ston, SC 29425 USA
Citazione:
H.C. Becker, "Animal models of alcohol withdrawal", ALCOHOL R H, 24(2), 2000, pp. 105

Abstract

One diagnostic criterion of alcohol dependence is the appearance of a withdrawal syndrome when alcohol consumption ceases. Researchers have used various animal models, including isolated brain cells, slices of brain tissue, and intact animals, to study the mechanisms and manifestations of withdrawal. Results from these experimental studies have demonstrated that many consequences of withdrawal found in animals resemble those observed in humans. Such signs and symptoms of alcohol withdrawal include enhanced activity of the autonomic nervous system; body posture and motor abnormalities; hyperexcitability of the central nervous system including sensory hyperreactivity;convulsions; anxiety; and psychological discomfort. Researchers also have used animal models to study the electrophysiological correlates of withdrawal, as well as neurobiological mechanisms underlying alcohol dependence andwithdrawal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:08:34