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Titolo:
Conserved and non-conserved regions in the sendai virus genome: Evolution of a gene possessing overlapping reading frames
Autore:
Fujii, Y; Kiyotani, K; Yoshida, T; Sakaguchi, T;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Bacteriol, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan
Titolo Testata:
VIRUS GENES
fascicolo: 1, volume: 22, anno: 2001,
pagine: 47 - 52
SICI:
0920-8569(200101)22:1<47:CANRIT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARAMYXOVIRUS SIMIAN-VIRUS-5 REQUIRES; NUCLEOTIDE-SEQUENCE; RNA-SYNTHESIS; P-PROTEIN; MESSENGER-RNA; C PROTEINS; V-PROTEIN; REPLICATION; PATHOGENESIS; MUTANT;
Keywords:
Sendai virus; paramyxovirus; nucleotide sequence; genome; overlapping reading frame; field strain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sakaguchi, T Hiroshima Univ, Sch Med, Dept Bacteriol, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348551 1, Japan
Citazione:
Y. Fujii et al., "Conserved and non-conserved regions in the sendai virus genome: Evolution of a gene possessing overlapping reading frames", VIRUS GENES, 22(1), 2001, pp. 47-52

Abstract

We have sequenced the entire genome of a virulent field isolate of Sendai virus, the Hamamatsu strain, and compared the sequence with that of a distant related strain, the Z strain. Calculation of synonymous and non-synonymous (amino acid changing) nucleotide substitutions revealed regions where changes were permissive and non-permissive, and the experimentally determinedfunctional region were found to be conserved, showing that important regions for function were conserved during evolution. In the cistron-overlappingregions in the P gene, one reading frame was conserved, whereas the other overlapping frame was flexible. The priority of one frame could be a strategy for evolution of an overlapping gene of RNA viruses. We found that the carboxyl two thirds of the C protein was conserved over the amino-terminal one third, possessing priority to the overlapping P polypeptide. This suggests that the carboxyl two thirds of the C protein have a functional importance. We also found a highly variable region between the L coding frame and the 5' trailer sequence. The relevance of these findings to actual viral replication should be clarified in the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:05:26