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Titolo:
Gender-dependent behavioral and sensory effects of a commercial mixture ofpolychlorinated biphenyls (Aroclor 1254) in rats
Autore:
Geller, AM; Oshiro, WM; Haykal-Coates, N; Kodavanti, PRS; Bushnell, PJ;
Indirizzi:
US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Lab, Res Triangle Pk, NC 27711 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 59, anno: 2001,
pagine: 268 - 277
SICI:
1096-6080(200102)59:2<268:GBASEO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE WISTAR RATS; PCB EXPOSURE; IN-UTERO; LACTATIONAL EXPOSURE; ESTROGEN-RECEPTOR; 3,3',4,4',5-PENTACHLOROBIPHENYL PCB-126; DEVELOPMENTAL EXPOSURE; SUSTAINED ATTENTION; VISUAL-CORTEX; HEARING-LOSS;
Keywords:
autoshaping; gender-dependent effects; Aroclor 1254; polychlorinated biphenyls; visual thresholds;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Geller, AM US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab,MD-74B, Res Triangle Pk, NC 27711 USA US EPA MD-74B Res Triangle Pk NC USA27711 gle Pk, NC 27711 USA
Citazione:
A.M. Geller et al., "Gender-dependent behavioral and sensory effects of a commercial mixture ofpolychlorinated biphenyls (Aroclor 1254) in rats", TOXICOL SCI, 59(2), 2001, pp. 268-277

Abstract

Developmental exposure to polychlorinated biphenyls (PCBs) has been associated with behavioral and cognitive deficits in humans and animal models. Perinatal exposure to PCBs has also been associated with sensory deficits in animal models. These effects were hypothesized to be mediated in part by ortho-substituted PCBs, which do not or weakly bind to the aryl hydrocarbon (Ah) receptor. The present studies were designed to determine whether perinatal exposure to Aroclor 1254, a commercial mixture of > 99% ortho-substituted PCBs, would affect cognitive and sensory function in Long-Evans rats. Adult male and female offspring of female rats fed Aroclor 1254 (Lot #124-191; doses of 0, 1, or 6 mg/kg/day; gestational day 6 through postnatal day 21; n = eight/group) were trained to perform a signal detection task capable of assessing sensory thresholds. Training included autoshaping and operant conditioning. Thresholds for detecting a 1-s light stimulus were determinedunder background illuminations ranging from 2 lux to complete darkness. Female rats exposed to Aroclor 1254 autoshaped more rapidly than control females, at a rate akin to control males. Control females had lower thresholds than control males at all levels of background illumination. These differences were abolished by Aroclor 1254, which reduced thresholds in males and increased thresholds in females. These data extend previous findings of gender-specific effects of PCBs on neurobehavioral development to measures of acquisition and sensory function.

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Documento generato il 26/01/20 alle ore 01:04:33