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Titolo:
Phenytoin intoxication induced by fluvoxamine
Autore:
Mamiya, K; Kojima, K; Yukawa, E; Higuchi, S; Ieiri, I; Ninomiya, H; Tashiro, N;
Indirizzi:
Hizen Natl Hosp, Saga 8420192, Japan Hizen Natl Hosp Saga Japan 8420192Hizen Natl Hosp, Saga 8420192, Japan Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka, Japan Kyushu Univ Fukuoka Japan h Med Sci, Dept Neuropsychiat, Fukuoka, Japan Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Clin Pharmacokinet, Fukuoka, Japan Kyushu Univ Fukuoka Japan Sci, Dept Clin Pharmacokinet, Fukuoka, Japan Tottori Univ, Fac Med, Dept Hosp Pharm, Yonago, Tottori 683, Japan TottoriUniv Yonago Tottori Japan 683 p Pharm, Yonago, Tottori 683, Japan
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 1, volume: 23, anno: 2001,
pagine: 75 - 77
SICI:
0163-4356(200102)23:1<75:PIIBF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; HUMAN LIVER; IN-VITRO; FLUOXETINE; METABOLISM; HYDROXYLATION; CYP2C9;
Keywords:
phenytoin; intoxication; fluvoxamine; drug interaction; CYP2C subfamily;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Mamiya, K Hizen Natl Hosp, 160 Mitsu, Saga 8420192, Japan Hizen Natl Hosp 160 Mitsu Saga Japan 8420192 aga 8420192, Japan
Citazione:
K. Mamiya et al., "Phenytoin intoxication induced by fluvoxamine", THER DRUG M, 23(1), 2001, pp. 75-77

Abstract

A patient had phenytoin intoxication after administration of fluvoxamine, a selective serotonin reuptake inhibitor. The serum concentration of phenytoin increased dramatically from 16.6 to 49.1 mug/mL when fluvoxamine was coadministered, although the daily dosage of phenytoin and other drugs had not changed. During phenytoin and fluvoxamine treatment, ataxia, a typical side effect of phenytoin, was observed. The genotypes of CYP2C9 and 2C19, theenzymes responsible for phenytoin metabolism, were homozygous for the wild-type alleles (CYP2C9*1/*1 and 2C19*1/ *1). The interaction may be a resultof inhibition of both CYP2C9 and 2C19 by fluvoxamine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:43:24