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Titolo:
Quantitative radioluminography of serotonin uptake sites in the porcine brain
Autore:
Cumming, P; Kretzschmar, M; Brust, P; Smith, DF;
Indirizzi:
Aarhus Univ, Hosp Psychiat, Dept Biol Psychiat, Inst Basic Res Psychiat, DK-8240 Risskov, Denmark Aarhus Univ Risskov Denmark DK-8240 s Psychiat, DK-8240 Risskov, Denmark Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C Univ Hosp, PET Ctr, Aarhus C, Denmark Rossendorf Inc, Forschungszentrum Rossendorf EV, Inst Bioorgan & Radiopharmaceut Chem, Dresden, Germany Rossendorf Inc Dresden Germany & Radiopharmaceut Chem, Dresden, Germany
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 351 - 355
SICI:
0887-4476(20010315)39:4<351:QROSUS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE; PIG BRAIN; RAT-BRAIN; PET; CITALOPRAM; BINDING; TRANSPORTER; DEPRESSION; CYANOIMIPRAMINE; INNERVATION;
Keywords:
serotonin uptake; receptor density; autoradiography; citalopram; fluoxetine; neuroanatomy; swine brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, DF Aarhus Univ, Hosp Psychiat, Dept Biol Psychiat, Inst Basic Res Psychiat, DK-8240 Risskov, Denmark Aarhus Univ Risskov Denmark DK-8240 , DK-8240 Risskov, Denmark
Citazione:
P. Cumming et al., "Quantitative radioluminography of serotonin uptake sites in the porcine brain", SYNAPSE, 39(4), 2001, pp. 351-355

Abstract

The regional density of serotonin uptake sites in porcine brain was determined by quantitative radioluminography. Brain cryostat sections 30 mum thick were cut in the sagittal plane and were incubated with [H-3]citalopram for selective labeling of serotonin uptake sites. The autoradiograms were quantified using tritium-sensitive radioluminography. The apparent affinity (K-D) of [H-3]citalopram for its binding sites in various brain regions ranged from 2.3-5.6 nM. The density of serotonin uptake sites was highest (200-300 fmol/mg tissue) in the amygdala, superior colliculus, and substantia nigra. Intermediate binding (100 fmol/mg tissue) was present in the dorsomedial thalamus, basal ganglia, and entorhinal cortex. Traces of specific binding (10 finol/mg tissue) were detected in the neocortex and cerebellar cortex. The findings show that the anatomic distribution of serotonin uptake sites in the porcine brain is similar to that reported in other mammals. The density was close to that reported in human brain and in rat brain. Synapse 39:351-355, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:59:26